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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Esmolol for the control of hypertension after neurologic surgery.

We sought to evaluate the effectiveness of esmolol vs placebo in 40 patients emerging from general anesthesia for neurosurgery. Efficacy was defined as a decrease in systolic blood pressure to within 20% above average ward pressure. The need for additional antihypertensive agents to control blood pressure was also used to define efficacy. During the infusion period 20 of 21 (95%) of the esmolol-treated patients and two of 19 (11%) of the patients receiving placebo had return of systolic blood pressure to within 20% of average ward pressure (p less than 0.001). One out of 21 (5%) esmolol-treated patients and 14 of 19 (74%) of the placebo group required intervention with additional antihypertensive medications (p less than 0.001). Esmolol was found to be effective in controlling hypertension that develops on emergence from general anesthesia in patients undergoing neurosurgery.[1]


  1. Esmolol for the control of hypertension after neurologic surgery. Gibson, B.E., Black, S., Maass, L., Cucchiara, R.F. Clin. Pharmacol. Ther. (1988) [Pubmed]
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