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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder.

Normal controls (NC) (n = 15), patients with panic disorder (PD) (n = 13) and patients with major depression (MD) (n = 17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine ( MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.[1]

References

  1. Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Kahn, R.S., Asnis, G.M., Wetzler, S., van Praag, H.M. Psychopharmacology (Berl.) (1988) [Pubmed]
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