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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of the thymus in natural tolerance to an autologous protein antigen.

C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5-deficient hosts repopulated with lymphoid cells from thymectomized C5-deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.[1]


  1. Role of the thymus in natural tolerance to an autologous protein antigen. Boguniewicz, M., Sunshine, G.H., Borel, Y. J. Exp. Med. (1989) [Pubmed]
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