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Ehrenpreis, S.

Analgesic properties of enkephalinase inhibitors: animal and human studies.

D-phenylalanine, bacitracin and puromycin produce long-lasting, naloxone-reversible analgesia in mice. Analgesic potency parallels potency of these compounds as inhibitors of met-enkephalin degradation by mouse brain enzymes. D-phenylalanine potentiates acupuncture analgesia in mice and humans and has been used to ameliorate a variety of human chronic pain conditions.[1]

References

Analgesic properties of enkephalinase inhibitors: animal and human studies. Ehrenpreis, S. Prog. Clin. Biol. Res. (1985) [Pubmed]

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