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Chemical Compound Review

BSPBio_001878     4-[[1-[4-[20- (aminocarbonylmethyl)-5-(3...

Synonyms: KBioGR_002286, KBioSS_001661, CCG-39928, NINDS_000769, SPBio_000698, ...
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Disease relevance of bacitracin


Psychiatry related information on bacitracin

  • When bacitracin disks were used for presumptive identification group A streptococci from clinical thorat specimens, 12.00% false positive and 0.00% false negative results were obtained as measured by the direct flourescent-antibody and Lancefield grouping methods [5].

High impact information on bacitracin


Chemical compound and disease context of bacitracin


Biological context of bacitracin

  • The selective susceptibility to bacitracin and carboxypeptidase inhibitor indicates that the catalytic sites of plaque and tangle-bound cholinesterases are more closely associated with peptidase or protease-like properties than the catalytic sites of cholinesterases in normal axons and cell bodies [15].
  • Mobile genetic elements in the form of IS elements and transposons are prominent in the genome and include a previously uncharacterized conjugative transposon and a composite transposon containing genes for the synthesis of antibiotics of the gramicidin/bacitracin family; however, no bacteriophage genomes are present [16].
  • Information is also scarce for bacitracin used only marginally in human and veterinary medicine and for streptogramin antibiotics [17].
  • Scatchard analysis indicates that, in the presence of bacitracin, VIP significantly decreases the affinity and increases the number of specific high affinity binding sites for [3H]5-HT in the dorsal hippocampus [18].
  • The PDI antibody, as well as bacitracin, inhibited tumor cell migration and invasion [19].

Anatomical context of bacitracin

  • Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase [20].
  • We also found that bacitracin, a potent inhibitor of the enzyme transglutaminase, neither prevents receptor internalization or degradation in human fibroblasts nor inhibits the mitogenic activity of epidermal growth factor [21].
  • These fragments were cultured overnight in medium containing serum and then preincubated in groups of three for 10 min in medium resembling cerebrospinal fluid in its electrolyte constituents and containing bacitracin [22].
  • Chloroquine (10 and 25 microM) did not inhibit cell pair formation, leading to the conclusion that inhibition by dansylcadaverine, methylamine, and bacitracin is not due to an alkalinization of the lysosome [23].
  • The formation of GlcNAc-lipid(s) in vitro was inhibited if membranes were prepared from cells previously treated with bacitracin [24].

Associations of bacitracin with other chemical compounds


Gene context of bacitracin

  • In addition, the interaction of AR or GR with RAF was competed by insulin and bacitracin, a competitive inhibitor of IDE [29].
  • The Drosophila IDE activity, like the mammalian enzymes, is inhibited by bacitracin and sulfhydryl-specific reagents [30].
  • This negative regulation of NF-kappaB was reversed by bacitracin, a PDI inhibitor [31].
  • Antibiotic sensitive clones appeared at a frequency of about 99% and were analyzed for deletions of gtfB, gtfC and a part of mbrA by the lack of insoluble glucan synthesis, sensitivity to bacitracin, and polymerase chain reaction [32].
  • Taken in conjunction with the previous finding that neither thiorphan nor bacitracin affected the conversion of endogenously synthesized big ET-1 in cultured endothelial cells, we conclude that physiologically relevant ECE found in the endothelial cells is more similar to M1 than to M2 [33].

Analytical, diagnostic and therapeutic context of bacitracin


  1. Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial. Smack, D.P., Harrington, A.C., Dunn, C., Howard, R.S., Szkutnik, A.J., Krivda, S.J., Caldwell, J.B., James, W.D. JAMA (1996) [Pubmed]
  2. Toxicity of mediastinal irrigation with bacitracin. Westerman, E.L. JAMA (1983) [Pubmed]
  3. Bacitracin treatment of antibiotic-associated colitis and diarrhea caused by Clostridium difficile toxin. Chang, T.W., Gorbach, S.L., Bartlett, J.G., Saginur, R. Gastroenterology (1980) [Pubmed]
  4. Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Young, G.P., Ward, P.B., Bayley, N., Gordon, D., Higgins, G., Trapani, J.A., McDonald, M.I., Labrooy, J., Hecker, R. Gastroenterology (1985) [Pubmed]
  5. Evaluation of the Bacti-Lab streptococci culture systems for selective recovery and identification of group A streptococci. Freeburg, P.W., Buckingham, J.M. J. Clin. Microbiol. (1976) [Pubmed]
  6. Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread. Li, Q., Ali, M.A., Cohen, J.I. Cell (2006) [Pubmed]
  7. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. Mallat, A., Pavoine, C., Dufour, M., Lotersztajn, S., Bataille, D., Pecker, F. Nature (1987) [Pubmed]
  8. Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study. Roscher, A.A., Manganiello, V.C., Jelsema, C.L., Moss, J. J. Clin. Invest. (1983) [Pubmed]
  9. Antibiotic-induced lysis of enterococci. Storch, G.A., Krogstad, D.J. J. Clin. Invest. (1981) [Pubmed]
  10. Colorectal spirochetosis: clinical significance of the infestation. Nielsen, R.H., Orholm, M., Pedersen, J.O., Hovind-Hougen, K., Teglbjaerg, P.S., Thaysen, E.H. Gastroenterology (1983) [Pubmed]
  11. Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction. Ryser, H.J., Levy, E.M., Mandel, R., DiSciullo, G.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Comparative review of topical ophthalmic antibacterial preparations. Robert, P.Y., Adenis, J.P. Drugs (2001) [Pubmed]
  13. In vitro synergy studies with Clostridium difficile. Bacon, A.E., McGrath, S., Fekety, R., Holloway, W.J. Antimicrob. Agents Chemother. (1991) [Pubmed]
  14. In Vitro Susceptibility of Clostridium difficile Clinical Isolates from a Multi-Institutional Outbreak in Southern Quebec, Canada. Bourgault, A.M., Lamothe, F., Loo, V.G., Poirier, L. Antimicrob. Agents Chemother. (2006) [Pubmed]
  15. Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease. Wright, C.I., Guela, C., Mesulam, M.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  16. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Ajdić, D., McShan, W.M., McLaughlin, R.E., Savić, G., Chang, J., Carson, M.B., Primeaux, C., Tian, R., Kenton, S., Jia, H., Lin, S., Qian, Y., Li, S., Zhu, H., Najar, F., Lai, H., White, J., Roe, B.A., Ferretti, J.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria. Butaye, P., Devriese, L.A., Haesebrouck, F. Clin. Microbiol. Rev. (2003) [Pubmed]
  18. Modulation by vasoactive intestinal peptide (VIP) of serotonin receptors in membranes from rat hippocampus. Rostene, W.H., Fischette, C.T., McEwen, B.S. J. Neurosci. (1983) [Pubmed]
  19. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Goplen, D., Wang, J., Enger, P.?.?., Tysnes, B.B., Terzis, A.J., Laerum, O.D., Bjerkvig, R. Cancer Res. (2006) [Pubmed]
  20. Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase. Mandel, R., Ryser, H.J., Ghani, F., Wu, M., Peak, D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  21. Lysosomotropic amines inhibit mitogenesis induced by growth factors. King, A.C., Hernaez-Davis, L., Cuatrecasas, P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  22. Acetylcholine, melatonin, and potassium depolarization stimulate release of luteinizing hormone-releasing hormone from rat hypothalamus in vitro. Richardson, S.B., Prasad, J.A., Hollander, C.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  23. Role for endocytosis in conjugation in Tetrahymena. Rotheim, M.B., Love, B. Mol. Cell. Biol. (1982) [Pubmed]
  24. Incorporation of N-acetyl-D-glucosamine from UDP-N-acetyl-D-glucosamine by isolated membranes of Bacillus subtilis. Identification of undecaprenyl poly(N-acetylglucosaminyl pyrophosphate). Bettinger, G.E., Chatterjee, A.N., Young, F.E. J. Biol. Chem. (1977) [Pubmed]
  25. Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes. Hammons, G.T., Smith, R.M., Jarett, L. J. Biol. Chem. (1982) [Pubmed]
  26. Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells. Naquet, P., Ellis, J., Singh, B., Hodges, R.S., Delovitch, T.L. J. Immunol. (1987) [Pubmed]
  27. Protein-disulfide isomerase-mediated reduction of the A subunit of cholera toxin in a human intestinal cell line. Orlandi, P.A. J. Biol. Chem. (1997) [Pubmed]
  28. Effect of bacitracin on retroendocytosis and degradation of insulin in cultured kidney epithelial cell line. Dahl, D.C., Tsao, T., Duckworth, W.C., Frank, B.H., Rabkin, R. Diabetes (1990) [Pubmed]
  29. Androgen and glucocorticoid receptors interact with insulin degrading enzyme. Kupfer, S.R., Wilson, E.M., French, F.S. J. Biol. Chem. (1994) [Pubmed]
  30. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Garcia, J.V., Fenton, B.W., Rosner, M.R. Biochemistry (1988) [Pubmed]
  31. Protein disulfide isomerase suppresses the transcriptional activity of NF-kappaB. Higuchi, T., Watanabe, Y., Waga, I. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  32. Unmarked gene deletion mutagenesis of gtfB and gtfC in Streptococcus mutans using a targeted hit-and-run strategy with a thermosensitive plasmid. Atlagic, D., Kiliç, A.O., Tao, L. Oral Microbiol. Immunol. (2006) [Pubmed]
  33. Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T., Kimura, S. Biochim. Biophys. Acta (1993) [Pubmed]
  34. Isolation of Epstein Barr-virus and studies of its neutralization by human IgG and complement. Nemerow, G.R., Cooper, N.R. J. Immunol. (1981) [Pubmed]
  35. Degradation of the neuropeptide somatostatin by cultivated neuronal and glial cells. Lucius, R., Mentlein, R. J. Biol. Chem. (1991) [Pubmed]
  36. A comparative study of polyantibiotic and iodophor ointments in prevention of vascular catheter-related infection. Maki, D.G., Band, J.D. Am. J. Med. (1981) [Pubmed]
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