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McConkey, E.H. et al.

Human heterozygosity: a new estimate.

Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.[1]

References

Human heterozygosity: a new estimate. McConkey, E.H., Taylor, B.J., Phan, D. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]

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