Erythromycin 2% gel in comparison with clindamycin phosphate 1% solution in acne vulgaris.
One hundred two patients with mild to moderate facial acne vulgaris completed a 12-week, investigator-masked, randomized, parallel-group comparison of a gel formation of erythromycin (2%) with clindamycin phosphate 1% solution. Patients were evaluated at a baseline visit and after 4, 8, and 12 weeks of twice-daily treatment. Both medications significantly reduced the numbers of papules and open and closed comedones. No significant differences in lesion count reductions were detected between the treatment groups after 8 and 12 weeks of treatment. By the end of 12 weeks, 48% of the patients in the erythromycin group and 47% in the clindamycin group had good or excellent responses to treatment. No patient was terminated from the study for side effects. Most patients, 65% in the erythromycin 2% gel group and 67% in the clindamycin phosphate 1% solution group, had a favorable impression of the overall cosmetic characteristics of their study medication.[1]References
- Erythromycin 2% gel in comparison with clindamycin phosphate 1% solution in acne vulgaris. Leyden, J.J., Shalita, A.R., Saatjian, G.D., Sefton, J. J. Am. Acad. Dermatol. (1987) [Pubmed]
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