Disease relevance of Acne Vulgaris

• PURPOSE: Prolonged treatment with minocycline for acne vulgaris has been associated with the development of arthralgia, arthritis, and other autoimmune phenomena [1].
• Androgenic symptoms (including hirsutism, seborrhoea, alopecia, acne vulgaris and hair and skin greasiness) improved in women treated with dienogest plus ethinylestradiol [2].
• All three presented a unique reaction manifested by fever, arthritis/arthralgia and livedo reticularis during treatment with minocycline for acne vulgaris [3].
• Minocycline is widely used in the treatment of acne vulgaris and uncommonly produces the side effect of hyperpigmentation [4].
• Perinuclear antineutrophilic cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris [5].

Psychiatry related information on Acne Vulgaris

• Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris [6].
• Frequently occurring skin irritancy and flare-up reactions impede the use of topical tretinoin for acne vulgaris due to poor patient compliance [7].

High impact information on Acne Vulgaris

• Bilateral nasal bone osteophytosis associated with short-term oral isotretinoin therapy for cystic acne vulgaris [8].
• Benzoyl peroxide (BPO) is a commonly used drug in the treatment of acne vulgaris, but it induces unwanted side effects related to stratum corneum (SC) function [9].
• Topical clindamycin and erythromycin have been proven to be effective against inflammatory acne vulgaris in concentrations of 1-4% with or without the addition of zinc [10].
• Adapalene (Differin) is a retinoid agent indicated for the topical treatment of acne vulgaris [11].
• Pharmacokinetics of tazarotene cream 0.1% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin [12].

Chemical compound and disease context of Acne Vulgaris

• Similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vulgaris [13].
• Direct analysis of resistance in the cutaneous microflora during treatment of acne vulgaris with topical 1% nadifloxacin and 2% erythromycin [14].
• Glycerol was measured in skin surface washings of acne vulgaris patients, in acne vulgaris patients treated for at least 3 mo with oral tetracycline and in control subjects [15].
• Topical tazarotene 0.1% gel significantly reduced lesion counts in patients with mild to moderate facial acne vulgaris [16].
• Vitamin A acid: a review of its pharmacological properties and therapeutic use in the topical treatment of acne vulgaris [17].

Biological context of Acne Vulgaris

• At standard application rates in patients with acne vulgaris, the maximum average C(max) and AUC values of tazarotenic acid were 0.10 +/- 0.06 microg/L (n = 8) and 1.54 +/- 1.01 microg. h/L (n = 8), respectively, and occurred on day 15 [12].
• Effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris [18].
• The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man [19].
• This study was undertaken to evaluate the effects of a single implant containing nomegestrol acetate (Uniplant) on plasma levels of sex hormone-binding globulin (SHBG), testosterone, free testosterone, androstenedione and on blood pressure, body weight, and the development of acne vulgaris [20].
• A general practice study investigating the effect of Minocin 50 mg b.d. for 12 weeks in the treatment of acne vulgaris [21].

Anatomical context of Acne Vulgaris

• Ophthalmological effects of 13-cis-retinoic acid therapy for acne vulgaris [22].
• We report the unusual case of a 29-year-old female who developed black discoloration of breast milk 3 weeks after commencing oral minocycline therapy for acne vulgaris [23].
• Thyroid carcinoma and hyperparathyroidism after radiation therapy for adolescent acne vulgaris [24].
• Steroid metabolism in human skin: its relation to sebaceous-gland growth and acne vulgaris [25].
• Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment [26].

Gene context of Acne Vulgaris

• Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses [27].
• Women with severe acne vulgaris had testosterone levels in the same range but the SHBG levels were significantly lower than those of healthy women and women with mild acne [28].
• Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris [29].
• We have investigated the expression patterns of two antimicrobial peptides, human beta-defensin 1 (hBD1) and human beta-defensin 2 (hBD2) in healthy human hair follicles as well as in peri- and intralesional skin of acne vulgaris lesions such as comedones, papules and pustules [30].
• Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris [31].

Analytical, diagnostic and therapeutic context of Acne Vulgaris

• Photodynamic therapy with topical aminolevulinic acid was tested for the treatment of acne vulgaris, in an open-label prospective human study [32].
• OBJECTIVE: To evaluate the safety and pharmacokinetics of tazarotene cream 0.1% under standard (face only) or exaggerated (15% body surface area, including the face) application conditions after a single dose and after repeat topical applications once daily to patients with acne vulgaris or photodamaged skin [12].
• Comparative efficacy of oral erythromycin versus oral tetracycline in the treatment of acne vulgaris. A double-blind study [33].
• Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris [34].
• A gel formulation of erythromycin 2 percent was compared with its vehicle in a double-blind multicenter study involving patients with mild to moderate acne vulgaris [35].

References