Disease relevance of Clindamycin phosphate

• A 42 year old heroin addict with Staphylococcus aureus endocarditis of the mitral valve was treated with clindamycin phosphate, 600 mg intramuscularly, every 6 hours [1].
• Fulminant pseudomembranous colitis caused by clindamycin phosphate vaginal cream [2].
• In recent clinical studies, clindamycin phosphate cream administered intravaginally has been shown to be efficacious in the treatment of bacterial vaginosis (BV) [3].
• Erythromycin 2% gel in comparison with clindamycin phosphate 1% solution in acne vulgaris [4].
• Fifty-one hospitalized women were treated with either clindamycin phosphate alone (N = 23) or a combination of clindamycin phosphate plus tobramycin (N = 28) for community-acquired pelvic inflammatory disease [5].

High impact information on Clindamycin phosphate

• Penetration of clindamycin phosphate into the abnormal human biliary tract [6].
• These results indicate that systemic exposure to clindamycin from intravaginal administration of clindamycin phosphate cream is minimal [3].
• Pharmacokinetics of clindamycin phosphate in the first year of life [7].
• The rankings of clindamycin phosphate lotion and erythromycin/zinc solution worsened from pre- to post-treatment, indicating a shift in patient preference after they experienced products 'in-use' during the study [8].
• An open-label, two-period, crossover study of the systemic bioavailability in healthy women of clindamycin phosphate from two vaginal cream formulations [9].

Chemical compound and disease context of Clindamycin phosphate

• This multicenter, randomized, investigator-blinded study investigated the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with clindamycin plus vehicle for the treatment of mild to moderate acne vulgaris [10].
• One hundred two patients with mild to moderate facial acne vulgaris completed a 12-week, investigator-masked, randomized, parallel-group comparison of a gel formation of erythromycin (2%) with clindamycin phosphate 1% solution [4].
• Topical clindamycin phosphate compared with oral tetracycline in the treatment of acne vulgaris [11].
• A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris [12].
• This study evaluated the effectiveness of topically applied clindamycin hydrochloride and clindamycin phosphate in two, nonprescription, antiacne hydroalcoholic products for the treatment of acne vulgaris [13].

Biological context of Clindamycin phosphate

• Clindamycin phosphate: neuromuscular and blood pressure effects in cats [14].
• Results indicated that clindamycin phosphate underwent hydrolysis in the eye, liberating the biologically active clindamycin [15].
• Early therapy, which included intravitreal clindamycin phosphate and gentamicin sulfate, resulted in a visual acuity of 20/60 [16].
• The kinetics of intraperitoneally administered clindamycin phosphate were studied in 9 volunteer subjects undergoing CAPD [17].
• Bioequivalence study of clindamycin phosphate injection (Clinott-P) in Thai healthy volunteers [18].

Anatomical context of Clindamycin phosphate

• Clindamycin phosphate, a new semisynthetic antibiotic that is effective in the treatment of toxoplasmosis and of infections caused by Gram-positive bacteria, was found to be highly concentrated in the choroid, iris, and retina of the pigmented rabbit eye after a single intramuscular injection of 75 mg/kg [19].
• Subconjunctival injection of clindamycin phosphate also produced sustained high levels of drug in the choroid, iris, and retina; but when 150 mg was injected in a volume of 1 ml, corneal edema and severe inflammation of the conjunctiva resulted [19].
• When admixed with dialysate fluid and instilled into the peritoneal cavity, clindamycin phosphate is rapidly activated [17].
• The concentration of clindamycin phosphate in blood from the uterus was tested in 30 women after administration of one single dose (600 mg) intramuscularly [20].
• Scanning electron microscopy of samples of infected bone tissue taken at necropsy revealed masses of coccoid profiles embedded in a matrix of condensed exopolysaccharide material which adhered to the bone in both infected control animals and in infected animals treated for 1 week with clindamycin phosphate [21].

Associations of Clindamycin phosphate with other chemical compounds

• Postoperative open wound was cleaned twice a day and intravenous infusions of 1g imipenem/cilastatin sodium and 1.2g clindamycin phosphate were administered daily [22].
• Topical tetracycline hydrochloride vs. topical clindamycin phosphate in the treatment of acne: a comparative study [23].
• A new HPLC method based on reverse phase separation and photodiode-array detection has been developed for the simultaneous determination of tretinoin and clindamycin phosphate, and their degradation products in topical formulations [24].
• Therefore, in this study the effects of commonly used antibiotics, namely sodium ampicillin, ciprofloxacin, rifamycin SV and clindamycin phosphate, on human PON1 were investigated in vitro and in vivo [25].

Analytical, diagnostic and therapeutic context of Clindamycin phosphate

• Each of 12 patients undergoing routine diagnostic upper gastrointestinal endoscopy received a single iv infusion of clindamycin phosphate 300 mg over 10 min [26].
• Thirty-two patients with acne completed a randomized, double-blind study using topical 1% clindamycin phosphate or its vehicle applied twice daily for 8 weeks for a study of its effects on the intestinal microflora [27].
• Following a single intravenous infusion of 600 mg of clindamycin phosphate, tissue levels were determined in operative specimens obtained from ten women [28].
• Group A patients (38 patients) were given 300 mg. of clindamycin phosphate every 6 hours, beginning with admission and lasting until 1 day following chest tube removal or for 5 days, whichever was shorter [29].
• Pseudomembranous colitis was observed on two occasions in the same patient and was associated with the topical administration of clindamycin phosphate [30].

References