Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes.
The subcellular distribution of the type II enzyme of cAMP-dependent protein kinase (cAMP-dPK II) in epithelial and fibroblastic cells was determined by indirect immunofluorescence microscopy. In interphase cells both regulatory (R II) and catalytic (C) subunits were concentrated in a perinuclear area. By comparison of the R II distribution with the location of a bona fide Golgi membrane constituent, this area was identified as the Golgi complex. The cytochemical localization of R II was confirmed by subcellular fractionation. In addition, cAMP-dPK II was associated with microtubule-organizing centers, in particular with mitotic spindle poles. These distributions of cAMP-dPK II probably represent important factors in mediating the effects of cAMP on basic cellular activities ranging from secretion and proliferation to cell shape and motility.[1]References
- Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes. Nigg, E.A., Schäfer, G., Hilz, H., Eppenberger, H.M. Cell (1985) [Pubmed]
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