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Klahr, S. et al.

Toxicity of parathyroid hormone in uremia.

The most significant complication of elevated parathyroid hormone ( PTH) levels in uremia is the development of osteitis fibrosa cystica. The hormone also appears to play a role in soft-tissue and organ calcification, metabolic abnormalities (glucose, lipids), and electroencephalographic changes seen in uremic patients. Its role in the hematological abnormalities of uremia (anemia, bleeding) is controversial. A role for PTH in heart and skeletal muscle dysfunction in uremia has not been clearly established. Further studies are required to establish PTH as a "universal" toxin in uremia.[1]

References

Toxicity of parathyroid hormone in uremia. Klahr, S., Slatopolsky, E. Annu. Rev. Med. (1986) [Pubmed]

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