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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Enhancement of mRNA nuclear transport by promoter elements.

This report describes studies on the kinetics of herpes thymidine kinase (TK) mRNA transport in X. laevis oocytes as studied by microinjection and microdissection. We show that TK mRNA nuclear transport in this cell can be dramatically altered by introduction of specific DNA sequences into the nucleus. Introduction of DNA sequences encompassing the promoter results in enhancement, in trans, of a transport process that can deliver previously synthesized RNA to the cytoplasm. The report suggests that the promoter of a eukaryotic gene can functionally interact with the mechanism involved in mRNA nuclear transport.[1]


  1. Enhancement of mRNA nuclear transport by promoter elements. de la Peña, P., Zasloff, M. Cell (1987) [Pubmed]
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