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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Histories of substance abuse in patients with postpsychotic depressions.

Forty-six schizophrenic or schizoaffective patients with operationally defined episodes of postpsychotic depression were assessed for previous histories of substance abuse. Thirty-five percent had histories of previous cannabis (marijuana) abuse. Additionally, 13% had also abused cocaine, 13% amphetamines, 11% hallucinogens, 4% sedatives, and 2% opiates. Patients with histories of substance abuse were younger and showed higher index ratings on a subscale of endogenous depressive features. These findings are considered in the context of a possible self-medication hypothesis of substance abuse. A history of substance abuse did not appear to be a contraindication to a therapeutic trial of adjunctive imipramine (Ciba Geigy Corp., Summit, NJ) for postpsychotic depression.[1]

References

  1. Histories of substance abuse in patients with postpsychotic depressions. Siris, S.G., Kane, J.M., Frechen, K., Sellew, A.P., Mandeli, J., Fasano-Dube, B. Comprehensive psychiatry. (1988) [Pubmed]
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