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Chemical Compound Review

Bayfidan     1-(4-chlorophenoxy)-3,3- dimethyl-1-(1,2,4...

Synonyms: Triaphol, Baytoan, Spinnaker, Triafol, Baytan, ...
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Disease relevance of Baytan


Psychiatry related information on Baytan


High impact information on Baytan

  • Japan. Summit seeks boost for life sciences [10].
  • The forthcoming World Summit on Sustainable Development is an unprecedented opportunity to place health higher on the environmental and development agenda [11].
  • A combination of 27- and 90-microns spheres resulted in focal mucosal inflammation, necrosis, and ulceration. "Summit" lesions with normal adjacent mucosa were observed 48 hours after embolization, with evidence of regeneration of the mucosa overlying the occluded vessels at 72 hours [12].
  • Ten years after the key Earth Summit in Rio, a key group of influential politicians in Britain are flagging up the need to support research into taxonomy as a basis for biodiversity studies ahead of this summer's meeting in South Africa. Nigel Williams reports [13].
  • The Second National Biotechnology Summit [14].

Chemical compound and disease context of Baytan

  • A randomized, double-blind, parallel-group clinical trial compared diclofenac sodium (Voltaren, Ciba-Geigy Summit, NJ) with aspirin for the treatment of acute sprains and/or strains of the knee or ankle [15].
  • How can postoperative ileus be prevented and treated? IMPACT consults. Proceedings of the 2nd Annual Cleveland Clinic Perioperative Medicine Summit [16].
  • PATIENTS AND METHODS: Twenty two eyes with hyperopia were treated with a Summit Technology OmniMed holmium laser by placing two rings of eight laser spots at 6.5 and 9 mm (centred on the visual axis) to produce a 4.00 diopters (D) correction [17].
  • Thalidomide (Thalomid, Celgene Corp., Summit, NJ), an angiogenesis inhibitor and immunomodulator that reduces tumor necrosis factor-alpha, is used for the treatment of multiple myeloma [18].
  • At the World Summit for Children (New York, 1990), a resolution was passed to eliminate vitamin A and iodine deficiencies and significantly reduce iron-deficiency anemia by the year 2000 [19].

Biological context of Baytan

  • Within each cleistothecium, nuclear segregation occurred independently of mitochondrial inheritance, as shown by segregation of resistance to the fungicide triadimenol and by segregation of avirulences to the wheat cultivars Galahad (Pm2), Armada (Pm4b), and Holger (Pm6) [20].
  • OBJECTIVE: To evaluate the effects of vehicle supplementation on serum estradiol (E2) delivery pharmacokinetics from the Ciba-Geigy (Summit, NJ) 0.1-mg Estraderm Patch [21].
  • This analysis summarizes the first report of the Society of Thoracic Surgeons National Congenital Heart Surgery Database Committee in association with Summit Medical Systems. Twenty-four centers joined the program at various dates of entry resulting in 18,894 enrolled patient records [22].
  • METHODS: High and low contrast visual acuity were measured on Bailey-Lovie logarithm of the minimum angle of resolution (LogMAR) charts under high and low illumination conditions on 105 photorefractive keratectomy patients who had been treated with the Summit (N = 60) or the VISX (N = 45) excimer laser [23].
  • PURPOSE: To evaluate the differences in epithelial wound healing following photorefractive keratectomy when performed with the Summit UV 200 LA and the VISX 20/20 excimer lasers [24].

Anatomical context of Baytan

  • Rabbit corneas were photoablated (Summit Omnimed, 193 nm, 5 mm diameter, 50 microns and 100 microns depth) [25].
  • METHODS: Eighteen eyes of 9 patients with a mean preoperative spherical equivalent refraction of +2.26 +/- 0.82 D (range, +1.13 to +4.00 D) underwent PRK with the Summit Apex Plus excimer laser following manual scraping of the epithelium [26].
  • After immunostaining, embryos exposed to 12.5-125 microM Triadimenol showed specific cranial nerve and ganglia abnormalities [27].
  • CONCLUSION: Removal of corneal epithelium with the Summit Excimed UV 200 LA excimer laser using multizone, multipass photoablation yields visual and refractive results that compare favorably with published PRK series with excellent short-term stability [28].
  • By contrast, 25-250 microM Triadimefon and 25-125 microM Triadimenol induced specific concentration-related teratogenic effects at the level of first and second branchial arches [27].

Associations of Baytan with other chemical compounds


Gene context of Baytan

  • BACKGROUND: An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women [33].
  • Patients with COPD were defined according to the Summit Database definition: requires therapy for the treatment of chronic pulmonary compromise or has an FEV1 <75% of predicted value [34].
  • The effect of the four triadimenol stereoisomers on the purified yeast lanosterol 14 alpha-demethylase (cytochrome P-45014DM), the primary target of azole antifungal agents, was studied [35].
  • Consumers and authors of Web-based materials must critically assess and evaluate that information; the Information Quality Tool developed by the Health Summit Working Group is suggested as an analytic framework useful in evaluating ATOD information [36].
  • Results of phase III excimer laser photorefractive keratectomy for myopia. The Summit PRK Study Group [37].

Analytical, diagnostic and therapeutic context of Baytan


  1. 2004 ASM Conference on the New Phage Biology: the 'Phage Summit'. Adhya, S., Black, L., Friedman, D., Hatfull, G., Kreuzer, K., Merril, C., Oppenheim, A., Rohwer, F., Young, R. Mol. Microbiol. (2005) [Pubmed]
  2. First International Summit on Kidney Disease Prevention, 25-27 July 2002: consensus document. Ramirez, S.P. J. Am. Soc. Nephrol. (2003) [Pubmed]
  3. Polymer conjugation reduces deferoxamine induced retinopathy in an albino rat model. Gehlbach, P.L., Purple, R.L., Hallaway, P.E., Hedlund, B.E. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  4. Effect of clioquinol, an 8-hydroxyquinoline derivative, on rotavirus infection in mice. Bednarz-Prashad, A.J., John, E.I. J. Infect. Dis. (1983) [Pubmed]
  5. One-year evaluation of myopic laser photoastigmatic refractive keratectomy using the summit apex plus: phase III of a Food and Drug Administration clinical trial. Haw, W.W., Manche, E.E. Ophthalmology (2000) [Pubmed]
  6. Histories of substance abuse in patients with postpsychotic depressions. Siris, S.G., Kane, J.M., Frechen, K., Sellew, A.P., Mandeli, J., Fasano-Dube, B. Comprehensive psychiatry. (1988) [Pubmed]
  7. Remission: Today's Target in the Treatment of Mood and Anxiety Disorders. Nemeroff, C.B. Psychopharmacology bulletin. (2002) [Pubmed]
  8. Obesity in Arkansas: from contemplation to action. The 2002 Arkansas Preventive Nutrition and Physical Activity Summit. Wheeler, J.G., Kahn, R.F., Garner, C.B., Vannatta, P.M. The Journal of the Arkansas Medical Society. (2004) [Pubmed]
  9. Rights and reality: monitoring the public's right to participate. Mock, G.A., Vanasselt, W.G., Petkova, E.I. International journal of occupational and environmental health : official journal of the International Commission on Occupational Health. (2003) [Pubmed]
  10. Japan. Summit seeks boost for life sciences. Normile, D. Science (2001) [Pubmed]
  11. Health and sustainable development: can we rise to the challenge? von Schirnding, Y. Lancet (2002) [Pubmed]
  12. A ferret model of acute multifocal gastrointestinal infarction. Hudson, M., Piasecki, C., Sankey, E.A., Sim, R., Wakefield, A.J., More, L.J., Sawyerr, A.M., Dhillon, A.P., Pounder, R.E. Gastroenterology (1992) [Pubmed]
  13. Biodiversity challenge to funding priorities. Williams, N. Curr. Biol. (2002) [Pubmed]
  14. The Second National Biotechnology Summit. Anderson, W.F. Hum. Gene Ther. (1995) [Pubmed]
  15. Comparison of diclofenac sodium and aspirin in the treatment of acute sports injuries. Duncan, J.J., Farr, J.E. The American journal of sports medicine. (1988) [Pubmed]
  16. How can postoperative ileus be prevented and treated? IMPACT consults. Proceedings of the 2nd Annual Cleveland Clinic Perioperative Medicine Summit. Singh, V. Cleveland Clinic journal of medicine. (2006) [Pubmed]
  17. Holmium:YAG laser thermokeratoplasty to correct hyperopia: two years follow-up. Tutton, M.K., Cherry, P.M. Ophthalmic surgery and lasers. (1996) [Pubmed]
  18. Thalidomide-induced organizing pneumonia. Feaver, A.A., McCune, D.E., Mysliwiec, A.G., Mysliwiec, V. South. Med. J. (2006) [Pubmed]
  19. Multiple-micronutrient fortification technology development and evaluation: from lab to market. Mehansho, H., Mellican, R.I., Hughes, D.L., Compton, D.B., Walter, T. Food and nutrition bulletin. (2003) [Pubmed]
  20. Isogamous, hermaphroditic inheritance of mitochondrion-encoded resistance to Qo inhibitor fungicides in Blumeria graminis f. sp. tritici. Robinson, H.L., Ridout, C.J., Sierotzki, H., Gisi, U., Brown, J.K. Fungal Genet. Biol. (2002) [Pubmed]
  21. Effects of vehicle supplementation on total estradiol absorption from a transdermal estradiol delivery system. Smith, R.D., Robinson, D.E., Delignieres, B., Albertson, B.D., Tomai, T.P., Zinaman, M.J., Simon, J.A. Fertil. Steril. (1991) [Pubmed]
  22. The Society of Thoracic Surgeons National Congenital Heart Surgery Database Report: analysis of the first harvest (1994-1997). Mavroudis, C., Gevitz, M., Ring, W.S., McIntosh, C.L., Schwartz, M. Ann. Thorac. Surg. (1999) [Pubmed]
  23. Assessment of high and low contrast visual acuity after photorefractive keratectomy for myopia. Gauthier, C.A., Holden, B.A., Epstein, D., Tengroth, B., Fagerholm, P., Hamberg-Nyström, H. Optometry and vision science : official publication of the American Academy of Optometry. (1998) [Pubmed]
  24. Comparison of corneal epithelial wound healing after photorefractive keratectomy in the rabbit with two types of excimer lasers. Hamberg-Nyström, H., van Setten, G.B., Fagerholm, P. Journal of refractive surgery (Thorofare, N.J. : 1995) (1997) [Pubmed]
  25. Corneal hyaluronan content during post-ablation healing: evidence for a transient depth-dependent contralateral effect. Drubaix, I., Legeais, J.M., Robert, L., Renard, G. Exp. Eye Res. (1997) [Pubmed]
  26. Prospective study of photorefractive keratectomy for hyperopia using an axicon lens and erodible mask. Haw, W.W., Manche, E.E. Journal of refractive surgery (Thorofare, N.J. : 1995) (2000) [Pubmed]
  27. In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol. Menegola, E., Broccia, M.L., Di Renzo, F., Prati, M., Giavini, E. In Vitro Cell. Dev. Biol. Anim. (2000) [Pubmed]
  28. Removal of corneal epithelium with phototherapeutic technique during multizone, multipass photorefractive keratectomy. Johnson, D.G., Kezirian, G.M., George, S.P., Casebeer, J.C., Ashton, J. Journal of refractive surgery (Thorofare, N.J. : 1995) (1998) [Pubmed]
  29. Simultaneous chiral separation of triadimefon and triadimenol by sulfated beta-cyclodextrin-mediated capillary electrophoresis. Wu, Y.S., Lee, H.K., Li, S.F. Electrophoresis (2000) [Pubmed]
  30. Rehabilitation Medicine Summit: Building Research Capacity--executive summary. Frontera, W.R., Fuhrer, M.J., Jette, A.M., Chan, L., Cooper, R.A., Duncan, P.W., Kemp, J.D., Ottenbacher, K.J., Peckham, P.H., Roth, E.J., Tate, D.G. Physical therapy. (2006) [Pubmed]
  31. Evaluation of a method based on liquid chromatography/electrospray tandem mass spectrometry for analyzing eight triazolic and pyrimidine fungicides in extracts of processed fruits and vegetables. Sannino, A. Journal of AOAC International. (2004) [Pubmed]
  32. The Atlantic Rim Telemedicine Summit. Boston, Massachusetts, USA, May 1997. Shannon, G.W. Telemedicine journal : the official journal of the American Telemedicine Association. (1997) [Pubmed]
  33. Breast cancer genetics in African Americans. Olopade, O.I., Fackenthal, J.D., Dunston, G., Tainsky, M.A., Collins, F., Whitfield-Broome, C. Cancer (2003) [Pubmed]
  34. Coronary artery bypass grafting in patients with COPD. Samuels, L.E., Kaufman, M.S., Morris, R.J., Promisloff, R., Brockman, S.K. Chest (1998) [Pubmed]
  35. Stereoselective interaction of an azole antifungal agent with its target, lanosterol 14 alpha-demethylase (cytochrome P-45014DM): a model study with stereoisomers of triadimenol and purified cytochrome P-45014DM from yeast. Yoshida, Y., Aoyama, Y. Chirality. (1990) [Pubmed]
  36. Internet-based information on alcohol, tobacco, and other drugs: issues of ethics, quality, and accountability. Monahan, G., Colthurst, T. Substance use & misuse. (2001) [Pubmed]
  37. Results of phase III excimer laser photorefractive keratectomy for myopia. The Summit PRK Study Group. Hersh, P.S., Stulting, R.D., Steinert, R.F., Waring, G.O., Thompson, K.P., O'Connell, M., Doney, K., Schein, O.D. Ophthalmology (1997) [Pubmed]
  38. The Women's Leadership Summit on Mammography held at the U.S. Capitol. Wittenberg, C.K. J. Natl. Cancer Inst. (1989) [Pubmed]
  39. Comparison of mechanical and transepithelial debridement during photorefractive keratectomy. Clinch, T.E., Moshirfar, M., Weis, J.R., Ahn, C.S., Hutchinson, C.B., Jeffrey, J.H. Ophthalmology (1999) [Pubmed]
  40. Photorefractive keratectomy versus laser in situ keratomileusis for moderate to high myopia. A randomized prospective study. Hersh, P.S., Brint, S.F., Maloney, R.K., Durrie, D.S., Gordon, M., Michelson, M.A., Thompson, V.M., Berkeley, R.B., Schein, O.D., Steinert, R.F. Ophthalmology (1998) [Pubmed]
  41. Corneal topography of excimer laser photorefractive keratectomy using a 6-mm beam diameter. Summit PRK Topography Study Group. Hersh, P.S., Shah, S.I. Ophthalmology (1997) [Pubmed]
  42. Haze following photorefractive and photoastigmatic refractive keratectomy with the Nidek EC5000 and the Summit ExciMed UV200. Goggin, M., Kenna, P., Lavery, F. Journal of cataract and refractive surgery. (1997) [Pubmed]
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