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MeSH Review

Marijuana Abuse

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Psychiatry related information on Marijuana Abuse


High impact information on Marijuana Abuse


Chemical compound and disease context of Marijuana Abuse

  • CONCLUSIONS: These data suggest that bupropion does not show promise as a potential treatment medication for marijuana dependence [11].
  • A history of marijuana abuse also was associated with higher levels of platelet adenylyl cyclase activities, and a history of major depression was associated with lower levels of forskolin- and CsF-stimulated activities [12].
  • Based on these preliminary data from three subjects, it is concluded that clonidine does not have therapeutic value in the clinical management of active marijuana abuse [13].
  • 1. Twenty-one schizophrenic or schizoaffective patients with histories of cannabis abuse and operationally-defined syndromes of post-psychotic depression completed a double-blind trial of adjunctive imipramine added to their on-going medication regimen of fluphenazine decanoate and benztropine [14].
  • The recent discovery of arachidonylethanolamide (anandamide), an endogenous ligand for cannabinoid receptors, and the synthesis of SR141716A, a cannabinoid antagonist selective for brain cannabinoid (CB1) receptors, have provided new tools to explore the mechanisms underlying cannabis abuse and dependence [15].

Biological context of Marijuana Abuse

  • To address this issue we examined the eye movements of 22 schizophrenic patients, 20 substance abusing patients (primarily alcohol; some with concomitant cocaine and/or cannabis abuse), and 17 normal controls during a visual pursuit task using infra-red oculography [16].

Gene context of Marijuana Abuse

  • Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse [17].
  • Further research is needed to clarify the relationship of stimulant dependence with QEEG changes and ADHD status, and to clarify the interactions of chronic stimulant and cannabis abuse on QEEG [18].
  • This might be reflected in the raised NGF-serum concentrations when both schizophrenia and long-term cannabis abuse prevail [19].
  • Patients with previous cannabis abuse had significantly more rehospitalizations, tended to worse psychosocial functioning, and scored significantly higher on the psychopathological syndromes "thought disturbance" (BPRS) and "hostility" (AMDP) [20].
  • A randomized controlled trial of brief cognitive-behavioral interventions (CBT) for cannabis dependence was undertaken to address this issue [21].

Analytical, diagnostic and therapeutic context of Marijuana Abuse


  1. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. McLellan, A.T., Lewis, D.C., O'Brien, C.P., Kleber, H.D. JAMA (2000) [Pubmed]
  2. Cannabinoid receptor gene (CNR1): association with i.v. drug use. Comings, D.E., Muhleman, D., Gade, R., Johnson, P., Verde, R., Saucier, G., MacMurray, J. Mol. Psychiatry (1997) [Pubmed]
  3. Gender and reported health problems in treated alcohol dependent Alaska natives. Parks, C.A., Hesselbrock, M.N., Hesselbrock, V.M., Segal, B. J. Stud. Alcohol (2001) [Pubmed]
  4. The effect of a history of alcohol dependence in adult major depression. Rae, A.M., Joyce, P.R., Luty, S.E., Mulder, R.T. Journal of affective disorders. (2002) [Pubmed]
  5. Connecting national survey data with DSM-IV criteria. van Dulmen, M.H., Grotevant, H.D., Dunbar, N., Miller, B.C., Bayley, B., Christensen, M., Fan, X. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (2002) [Pubmed]
  6. Escalation of drug use in early-onset cannabis users vs co-twin controls. Lynskey, M.T., Heath, A.C., Bucholz, K.K., Slutske, W.S., Madden, P.A., Nelson, E.C., Statham, D.J., Martin, N.G. JAMA (2003) [Pubmed]
  7. Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. Lynskey, M.T., Glowinski, A.L., Todorov, A.A., Bucholz, K.K., Madden, P.A., Nelson, E.C., Statham, D.J., Martin, N.G., Heath, A.C. Arch. Gen. Psychiatry (2004) [Pubmed]
  8. Medication development for addictive disorders: the state of the science. Vocci, F.J., Acri, J., Elkashef, A. The American journal of psychiatry. (2005) [Pubmed]
  9. Marijuana withdrawal in humans: effects of oral THC or divalproex. Haney, M., Hart, C.L., Vosburg, S.K., Nasser, J., Bennett, A., Zubaran, C., Foltin, R.W. Neuropsychopharmacology (2004) [Pubmed]
  10. Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. Gatley, S.J., Lan, R., Volkow, N.D., Pappas, N., King, P., Wong, C.T., Gifford, A.N., Pyatt, B., Dewey, S.L., Makriyannis, A. J. Neurochem. (1998) [Pubmed]
  11. Bupropion SR worsens mood during marijuana withdrawal in humans. Haney, M., Ward, A.S., Comer, S.D., Hart, C.L., Foltin, R.W., Fischman, M.W. Psychopharmacology (Berl.) (2001) [Pubmed]
  12. Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. Hoffman, P.L., Glanz, J., Tabakoff, B. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  13. Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marijuana in male human subjects. Cone, E.J., Welch, P., Lange, W.R. Pharmacol. Biochem. Behav. (1988) [Pubmed]
  14. Adjunctive imipramine for dysphoric schizophrenic patients with past histories of cannabis abuse. Siris, S.G., Bermanzohn, P.C., Mason, S.E., Rifkin, A., Alvir, J.M. Prog. Neuropsychopharmacol. Biol. Psychiatry (1992) [Pubmed]
  15. Cannabis: discrimination of "internal bliss"? Wiley, J.L. Pharmacol. Biochem. Behav. (1999) [Pubmed]
  16. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking. A comparison of schizophrenics with normals and substance abusing controls. Radant, A.D., Hommer, D.W. Schizophr. Res. (1992) [Pubmed]
  17. Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. Jockers-Scherübl, M.C., Danker-Hopfe, H., Mahlberg, R., Selig, F., Rentzsch, J., Schürer, F., Lang, U.E., Hellweg, R. Neurosci. Lett. (2004) [Pubmed]
  18. Quantitative EEG findings associated with chronic stimulant and cannabis abuse and ADHD in an adult male substance use disorder population. Trudeau, D.L., Thuras, P., Stockley, H. Clinical EEG (electroencephalography). (1999) [Pubmed]
  19. Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. Jockers-Scherübl, M.C., Matthies, U., Danker-Hopfe, H., Lang, U.E., Mahlberg, R., Hellweg, R. J. Psychopharmacol. (Oxford) (2003) [Pubmed]
  20. Cannabis and schizophrenia: results of a follow-up study. Caspari, D. European archives of psychiatry and clinical neuroscience. (1999) [Pubmed]
  21. Clinical profile of participants in a brief intervention program for cannabis use disorder. Copeland, J., Swift, W., Rees, V. Journal of substance abuse treatment. (2001) [Pubmed]
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