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Pawlikowski, M. et al.

Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.

The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay. It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands. The results indicated that benzodiazepines might exert an antiproliferative action on glioma tumour cells growth.[1]

References

Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. Pawlikowski, M., Kunert-Radek, J., Radek, A., Stepien, H. Acta neurologica Scandinavica. (1988) [Pubmed]

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