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Santoro, T.J. et al.

Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice.

Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5-lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.[1]

References

Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice. Santoro, T.J., Morris, D.H., Murphy, R.C., Baker, R.C. J. Exp. Med. (1988) [Pubmed]

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