Gene Review:
Alox5 - arachidonate 5-lipoxygenase
Mus musculus
Synonyms:
5-LO, 5-LOX, 5-lipoxygenase, 5LO, 5LX, ...
- Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. Bozza, P.T., Payne, J.L., Goulet, J.L., Weller, P.F. J. Exp. Med. (1996)
- Altered inflammatory responses in leukotriene-deficient mice. Goulet, J.L., Snouwaert, J.N., Latour, A.M., Coffman, T.M., Koller, B.H. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. Peebles, R.S., Hashimoto, K., Sheller, J.R., Moore, M.L., Morrow, J.D., Ji, S., Elias, J.A., Goleniewska, K., O'neal, J., Mitchell, D.B., Graham, B.S., Zhou, W. J. Immunol. (2005)
- Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation. Nakamura, Y., Kozuka, M., Naniwa, K., Takabayashi, S., Torikai, K., Hayashi, R., Sato, T., Ohigashi, H., Osawa, T. Free Radic. Biol. Med. (2003)
- Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Kisley, L.R., Barrett, B.S., Dwyer-Nield, L.D., Bauer, A.K., Thompson, D.C., Malkinson, A.M. Carcinogenesis (2002)
- 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior. Uz, T., Dimitrijevic, N., Tueting, P., Manev, H. Restorative neurology and neuroscience. (2002)
- Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Mehrabian, M., Allayee, H., Stockton, J., Lum, P.Y., Drake, T.A., Castellani, L.W., Suh, M., Armour, C., Edwards, S., Lamb, J., Lusis, A.J., Schadt, E.E. Nat. Genet. (2005)
- Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Peppelenbosch, M.P., Tertoolen, L.G., den Hertog, J., de Laat, S.W. Cell (1992)
- The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Zhao, L., Moos, M.P., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N., Schmidt, S., Spanbroek, R., Lötzer, K., Huang, L., Cui, J., Rader, D.J., Evans, J.F., Habenicht, A.J., Funk, C.D. Nat. Med. (2004)
- Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. Segal, B.H., Kuhns, D.B., Ding, L., Gallin, J.I., Holland, S.M. J. Leukoc. Biol. (2002)
- Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein e-deficient mice? Funk, C.D., Cao, R.Y., Zhao, L., Habenicht, A.J. Ann. N. Y. Acad. Sci. (2006)
- Distinct Effects of Annexin A7 and p53 on Arachidonate Lipoxygenation in Prostate Cancer Cells Involve 5-Lipoxygenase Transcription. Torosyan, Y., Dobi, A., Naga, S., Mezhevaya, K., Glasman, M., Norris, C., Jiang, G., Mueller, G., Pollard, H., Srivastava, M. Cancer Res. (2006)
- 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Hennig, R., Grippo, P., Ding, X.Z., Rao, S.M., Buchler, M.W., Friess, H., Talamonti, M.S., Bell, R.H., Adrian, T.E. Cancer Res. (2005)
- Cloning and functional analysis of the mouse 5-lipoxygenase promoter. Silverman, E.S., Le, L., Baron, R.M., Hallock, A., Hjoberg, J., Shikanai, T., Storm van's Gravesande, K., Auron, P.E., Lu, W. Am. J. Respir. Cell Mol. Biol. (2002)
- 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers. Green, J.A., Stockton, R.A., Johnson, C., Jacobson, B.S. Am. J. Physiol., Cell Physiol. (2004)
- Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. Wang, X.J., Dyson, M.T., Jo, Y., Eubank, D.W., Stocco, D.M. J. Steroid Biochem. Mol. Biol. (2003)
- Immunoregulatory properties of novel specific inhibitors of 5-lipoxygenase. Liu, D.S., Liew, F.Y., Rhodes, J. Immunopharmacology (1989)
- Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. Chiang, N., Gronert, K., Clish, C.B., O'Brien, J.A., Freeman, M.W., Serhan, C.N. J. Clin. Invest. (1999)
- Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Liao, T., Ke, Y., Shao, W.H., Haribabu, B., Kaplan, H.J., Sun, D., Shao, H. Invest. Ophthalmol. Vis. Sci. (2006)
- Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Bas, E., Recio, M.C., Giner, R.M., Máñez, S., Cerdá-Nicolás, M., Ríos, J.L. Planta Med. (2006)
- Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils. Hsu, M.F., Lin, C.N., Lu, M.C., Wang, J.P. Naunyn Schmiedebergs Arch. Pharmacol. (2004)
- Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. Rossi, A., Acquaviva, A.M., Iuliano, F., Di Paola, R., Cuzzocrea, S., Sautebin, L. J. Leukoc. Biol. (2005)
- Co-Administration of Acetyl-11-Keto-beta-Boswellic Acid, a Specific 5-Lipoxygenase Inhibitor, Potentiates the Protective Effect of COX-2 Inhibitors in Kainic Acid-Induced Neurotoxicity in Mice. Bishnoi, M., Patil, C.S., Kumar, A., Kulkarni, S.K. Pharmacology (2007)
- Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanism. Harizi, H., Juzan, M., Moreau, J.F., Gualde, N. J. Immunol. (2003)
- Evidence that secretory phospholipase A2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells. Fonteh, A.N., Bass, D.A., Marshall, L.A., Seeds, M., Samet, J.M., Chilton, F.H. J. Immunol. (1994)
- Involvement of unique mechanisms in the induction of scratching behavior in BALB/c mice by compound 48/80. Inagaki, N., Igeta, K., Kim, J.F., Nagao, M., Shiraishi, N., Nakamura, N., Nagai, H. Eur. J. Pharmacol. (2002)
- Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. Goulet, J.L., Griffiths, R.C., Ruiz, P., Spurney, R.F., Pisetsky, D.S., Koller, B.H., Coffman, T.M. J. Immunol. (1999)
- Synthesis of sterols and 5-lipoxygenase products are required for the G1-S phase transition of interleukin-2-dependent lymphocyte proliferation. Hata, S., Sugama, K., You-Li, Z., Hatanaka, M., Namba, Y., Hanaoka, M. Microbiol. Immunol. (1987)
- Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Son, M.J., Moon, T.C., Lee, E.K., Son, K.H., Kim, H.P., Kang, S.S., Son, J.K., Lee, S.H., Chang, H.W. Arch. Pharm. Res. (2006)
- Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor. Rao, T.S., Yu, S.S., Djuric, S.W., Isakson, P.C. Journal of lipid mediators and cell signalling. (1994)
- The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse. Bosetti, F., Weerasinghe, G.R. J. Neurochem. (2003)
- Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. Goulet, J.L., Griffiths, R.C., Ruiz, P., Mannon, R.B., Flannery, P., Platt, J.L., Koller, B.H., Coffman, T.M. J. Immunol. (2001)
- cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. Chen, X.S., Naumann, T.A., Kurre, U., Jenkins, N.A., Copeland, N.G., Funk, C.D. J. Biol. Chem. (1995)
- Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. Benjamim, C.F., Canetti, C., Cunha, F.Q., Kunkel, S.L., Peters-Golden, M. J. Immunol. (2005)
- 5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock. Cuzzocrea, S., Rossi, A., Serraino, I., Di Paola, R., Dugo, L., Genovese, T., Caputi, A.P., Sautebin, L. Shock (2003)