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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures.

Well-controlled prospective studies have shown the benefits of converting treatment for patients with epilepsy from polytherapy to monotherapy. Results of trials with valproate have demonstrated its efficacy as monotherapy in patients with generalized tonic-clonic seizures. Several studies have found no significant differences between valproate and phenytoin and carbamazepine in the treatment of partial seizures. In studies in which patients were diagnosed as having one of the primary generalized epilepsies, the response rate of tonic-clonic seizures to valproate establishes valproate as the drug of choice in the epilepsy syndromes with primary generalized tonic-clonic seizures.[1]


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