Alternative promoter usage by aldolase A during in vitro myogenesis.
Aldolase A in the mouse, as in human and rat, shows tissue-specific variability of message size. In addition, in muscle tissue the mRNA size is also developmentally regulated. In order to determine whether this muscle-specific regulatory mechanism can be reproduced in vitro, we have examined the mRNA species of aldolase A isolated from mouse C2C12 myoblasts and myotubes on Northern blots and by primer extension. We show that aldolase A mRNA increases during in vitro myogenesis; that this induction is accompanied by a change in the message population; and that this change is due to activation of a muscle-specific alternative promoter.[1]References
- Alternative promoter usage by aldolase A during in vitro myogenesis. Colbert, M.C., Ciejek-Baez, E. Dev. Biol. (1988) [Pubmed]
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