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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.

A cDNA clone corresponding to the complete amino acid sequence of a putative protease CCP2 of murine cytotoxic T lymphocytes was isolated and sequenced. The clone encodes a 248-residue long serine esterase. The deduced N-terminal amino acid sequence is identical over 40 residues to that of granzyme C, a protease of unknown function present in granules of cytotoxic lymphocytes. Analysis of the sequence of granzyme C/CCP2 reveals high homology to other granzyme proteases, i.e. granzyme A (40%) and granzyme B (67%) and to rat mast cell protease II (46%). The amino acids lining the specificity pocket are well conserved between granzyme B, C, and rat mast cell protease II, but not granzyme A, suggesting a similar general specificity of these three proteases.[1]

References

  1. cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes. Jenne, D., Rey, C., Masson, D., Stanley, K.K., Herz, J., Plaetinck, G., Tschopp, J. J. Immunol. (1988) [Pubmed]
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