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Gene Review

Gzmc  -  granzyme C

Mus musculus

Synonyms: AI323531, B10, CCP2, Ctla-5, Ctla5, ...
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Disease relevance of Gzmc


Psychiatry related information on Gzmc

  • At 1 h post-training, both contextual and cued fear memory deficits were more widespread: all strains except for B6 and B10 showed impairments of both types of memory [6].

High impact information on Gzmc

  • In this study we started with a peptide that was immunogenic in B10 mice; it was thus known to be able to interact with the MHC molecule, and T cells existed which could recognise the peptide-MHC complex [7].
  • Here we present evidence that individual male mice (B10) made tolerant to two different H-2 haplotypes (B10.BR, B10.D2) can transmit the tolerance state to each haplotype independently, yet often simultaneously, at a high frequency to both first and second generation progeny [8].
  • In contrast, donor cells could not be propagated from the bone marrow or other lymphoid tissues of nonimmunosuppressed C3H mice rejecting cardiac allografts from the same donor strain (B10) [9].
  • Further evidence that the GM-CSF-stimulated class IIdim or class II-depleted hepatic NPC were immature DC was obtained by injecting them into allogeneic B10 (H-2b I-E-) recipients [10].
  • To examine the effect of H-2a expressed only on radioresistant host elements, we prepared fully allogeneic chimeras by administering B10 bone marrow to lethally irradiated B10.A recipients [11].

Chemical compound and disease context of Gzmc

  • Among the various B10 and C3H strains, significant differences in the development of diabetes (hyperglycemia) are noted demonstrating that genes within the H-2 complex influence the susceptibility to the diabetogenic effect of low-dose streptozotocin treatment [12].
  • Clone B10, specific for the viral coat m.w. 70,000 glycoprotein, could be rapidly activated in situ after local transfer with intact tumor cells in syngeneic hosts to produce a delayed-type hypersensitivity reaction [13].
  • Congenic and double congenic mice expressing different H-7 alleles with varying H-2 haplotypes on the C57BL/10 (B10) background were tested for their susceptibility to Friend virus (FV) infection [14].
  • The 65-kDa stress protein from Mycobacterium bovis (Bacillus Calmette Guérin) elicited T cell proliferation and antibody responses in seven B10 congenic mouse strains with different H-2 haplotypes [15].
  • To determine the locus in the H-2 complex that affects susceptibility to the development of pulmonary adenomas in mice, H-2 congenic and recombinant strains of mice with A/Wy, BALB/c, C3H, and B10 backgrounds were subjected to treatment with urethane [16].

Biological context of Gzmc


Anatomical context of Gzmc


Associations of Gzmc with chemical compounds

  • Dexamethasone induces the synthesis of a phospholipase A2-inhibitory protein (PLIP) of molecular weight approximately equal to 55,000 from calf thymus and PLIPs of molecular weights 55,000, 40,000, 28,000, and 15,000 from A/J mouse thymus and from 12-day embryonic B10 [21].
  • The S-DIC subline, when exposed for 8 to 12 transplant generations to dimethyltriazenoimidazolecarboxamide, became immunogenic for syngeneic B10 mice, as judged from prolongation of survival time [22].
  • B10 (H-2b) mice conditioned with ALG on day -3, 300 cGy of TBI with transplantation of B10.BR (H-2k) or BALB/c (H-2d) BM on day 0, and CyP on day +2 exhibited evidence of donor chimerism (49.6 +/- 3.7% and 38.2 +/- 2.4%, respectively) in 97% of recipients [23].
  • Low-dose streptozotocin treatment was performed in mice of H-2 congenic strains on B10, C3H, or A background [12].
  • We have studied the idiotype and fine specificity of the secondary immune response to phosphocholine (PC) in C57BL (B10, B10.D2, and B.C8) and BALB (BALB/c, BAB-14, and C.B20) congenic strains of mice [24].

Enzymatic interactions of Gzmc

  • Granzyme C branched off first after the primate-rodent split and was involved in a recombination event with granzyme B before the rat-mouse divergence [25].

Regulatory relationships of Gzmc


Other interactions of Gzmc

  • These characteristics are also shared with the CCP1 and CCP2 genes, the charter members of the CCP gene family [27].
  • The association of Vbeta family bias and IL-4 inducibility in thymus CD161-CD44lowCD4+CD8- T cells is found for B6, B10, BALB/c, CBA, B10.A(4R), and ICR mouse strains [28].
  • An (SJL/J x B10. S)F1 x B10.S backcross was analyzed, and one quantitative trait locus (QTL) was located in the telomeric region of chromosome 10 close to the Ifng locus [29].
  • BM from B10 (H2b) mice given FL (10 microg/day; days 0-8; FL-BM) contained a 7-fold higher incidence of potentially tolerogenic immature CD11c+ DC (CD40low, CD80low, CD86low, MHC IIlow) that induced alloantigen-specific T cell hyporesponsiveness in vitro [30].
  • Consistent with this, expressions of the inducible isoform of NO synthase (iNOS) protein and mRNA were significantly higher in the spleen of B10 mice than in that of BALB/c mice [3].

Analytical, diagnostic and therapeutic context of Gzmc


  1. Immortalized intrahepatic mouse biliary epithelial cells: immunologic characterization and immunogenicity. Hreha, G., Jefferson, D.M., Yu, C.H., Grubman, S.A., Alsabeh, R., Geller, S.A., Vierling, J.M. Hepatology (1999) [Pubmed]
  2. Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection. Hussell, T., Georgiou, A., Sparer, T.E., Matthews, S., Pala, P., Openshaw, P.J. J. Immunol. (1998) [Pubmed]
  3. Dissection of strain difference in acquired protective immunity against Mycobacterium bovis Calmette-Guérin bacillus (BCG). Macrophages regulate the susceptibility through cytokine network and the induction of nitric oxide synthase. Yoshida, A., Koide, Y., Uchijima, M., Yoshida, T.O. J. Immunol. (1995) [Pubmed]
  4. Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment. Tanghe, A., Denis, O., Lambrecht, B., Motte, V., van den Berg, T., Huygen, K. Infect. Immun. (2000) [Pubmed]
  5. Dual roles for class II major histocompatibility complex molecules in staphylococcal enterotoxin-induced cytokine production and in vivo toxicity. Grossman, D., Lamphear, J.G., Mollick, J.A., Betley, M.J., Rich, R.R. Infect. Immun. (1992) [Pubmed]
  6. Mouse models of impaired fear memory exhibit deficits in amygdalar LTP. Schimanski, L.A., Nguyen, P.V. Hippocampus. (2005) [Pubmed]
  7. Failure to find holes in the T-cell repertoire. Ogasawara, K., Maloy, W.L., Schwartz, R.H. Nature (1987) [Pubmed]
  8. Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice. Gorczynski, R.M., Steele, E.J. Nature (1981) [Pubmed]
  9. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. Lu, L., Rudert, W.A., Qian, S., McCaslin, D., Fu, F., Rao, A.S., Trucco, M., Fung, J.J., Starzl, T.E., Thomson, A.W. J. Exp. Med. (1995) [Pubmed]
  10. Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. Lu, L., Woo, J., Rao, A.S., Li, Y., Watkins, S.C., Qian, S., Starzl, T.E., Demetris, A.J., Thomson, A.W. J. Exp. Med. (1994) [Pubmed]
  11. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. Sykes, M., Harty, M.W., Karlhofer, F.M., Pearson, D.A., Szot, G., Yokoyama, W. J. Exp. Med. (1993) [Pubmed]
  12. Genetic control of low-dose streptozotocin-induced autoimmune diabetes in mice. Kiesel, U., Falkenberg, F.W., Kolb, H. J. Immunol. (1983) [Pubmed]
  13. Adoptive chemoimmunotherapy of murine leukemia with helper T lymphocyte clones. Bookman, M.A., Swerdlow, R., Matis, L.A. J. Immunol. (1987) [Pubmed]
  14. Use of H-2:H-7 congenic mice to study H-2-mediated resistance to Friend leukemia virus. Wettstein, P.J., Blank, K.J. J. Immunol. (1982) [Pubmed]
  15. Differential pattern of T cell recognition of the 65-kDa mycobacterial antigen following immunization with the whole protein or peptides. Brett, S.J., Lamb, J.R., Cox, J.H., Rothbard, J.B., Mehlert, A., Ivanyi, J. Eur. J. Immunol. (1989) [Pubmed]
  16. The H-2 class II genes and the susceptibility to the development of pulmonary adenoma in mice. Miyashita, N., Moriwaki, K., Migita, S. Immunogenetics (1989) [Pubmed]
  17. cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes. Jenne, D., Rey, C., Masson, D., Stanley, K.K., Herz, J., Plaetinck, G., Tschopp, J. J. Immunol. (1988) [Pubmed]
  18. Cell death induced by granzyme C. Johnson, H., Scorrano, L., Korsmeyer, S.J., Ley, T.J. Blood (2003) [Pubmed]
  19. Second-set rejection of mouse liver allografts is dependent on radiation-sensitive nonparenchymal cells of graft bone marrow origin. Fu, F., Thai, N.L., Li, Y., Lu, L., Thomson, A.W., Fung, J.J., Qian, S. Transplantation (1996) [Pubmed]
  20. Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli. Garcia-Sanz, J.A., Velotti, F., MacDonald, H.R., Masson, D., Tschopp, J., Nabholz, M. Immunology (1988) [Pubmed]
  21. Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate glucocorticoid teratogenicity in vitro. Gupta, C., Katsumata, M., Goldman, A.S., Herold, R., Piddington, R. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  22. Changes of the immunogenic properties of a radiation-induced mouse lymphoma following treatment with antitumor drugs. Bonmassar, E., Testorelli, C., Franco, P., Goldin, A., Cudkowicz, G. Cancer Res. (1975) [Pubmed]
  23. Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach. Colson, Y.L., Li, H., Boggs, S.S., Patrene, K.D., Johnson, P.C., Ildstad, S.T. J. Immunol. (1996) [Pubmed]
  24. Regulation of T15 idiotype dominance. II. Genes unlinked to the Igh locus regulate T15 dominance of the secondary adoptive transfer response to phosphocholine. Wicker, L.S., Guelde, G., Scher, I., Kenny, J.J. J. Immunol. (1985) [Pubmed]
  25. Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases. Jenne, D.E., Masson, D., Zimmer, M., Haefliger, J.A., Li, W.H., Tschopp, J. Biochemistry (1989) [Pubmed]
  26. Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines. Masuda, R., Sakiyama, H., Nonaka, T., Kwan, A., Nakagawa, K., Moriya, H., Imajoh-Ohmi, S., Honjo, M., Yoshida, K. Cell Tissue Res. (2001) [Pubmed]
  27. Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5. Prendergast, J.A., Pinkoski, M., Wolfenden, A., Bleackley, R.C. J. Mol. Biol. (1991) [Pubmed]
  28. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. Chen, Y.T., Kung, J.T. J. Immunol. (2005) [Pubmed]
  29. Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice. Bihl, F., Brahic, M., Bureau, J.F. Genetics (1999) [Pubmed]
  30. Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. Morelli, A.E., Antonysamy, M.A., Takayama, T., Hackstein, H., Chen, Z., Qian, S., Zurowski, N.B., Thomson, A.W. J. Immunol. (2000) [Pubmed]
  31. Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival. Takayama, T., Kaneko, K., Morelli, A.E., Li, W., Tahara, H., Thomson, A.W. Transplantation (2002) [Pubmed]
  32. Nephritogenic T cells use granzyme C as a cytotoxic mediator. Bailey, N.C., Kelly, C.J. Eur. J. Immunol. (1997) [Pubmed]
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