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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid.

When 2 clinical strains of plasmid-mediated penicillin-resistant Staphylococcus aureus were treated with 1 mM sodium ascorbate for 6 h, 12-35% colony-forming units (CFU) irreversibly lost their ability to produce beta-lactamase. Agarose gel electrophoresis showed the disappearance of the plasmid bands from the lysates of colonies in which susceptibility to penicillin was induced by ascorbate treatment. Since ascorbic acid is a compound that is completely non-toxic, the possibility of its therapeutic use in the treatment of multiresistant bacterial diseases is proposed.[1]

References

  1. Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid. Amábile Cuevas, C.F. Mutat. Res. (1988) [Pubmed]
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