- Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein are decreased in streptozocin-induced diabetes. Possible marker for diabetic osteopenia. Ishida, H., Seino, Y., Taminato, T., Usami, M., Takeshita, N., Seino, Y., Tsutsumi, C., Moriuchi, S., Akiyama, Y., Hara, K. Diabetes (1988)