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Chemical Compound Review

hydroxyproline     (2S,4R)-4-hydroxypyrrolidine- 2-carboxylic...

Synonyms: Hypro, hydroxiproline, H-Hyp-OH, L-HYP-OH, h-l-hyp-oh, ...
 
 
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Disease relevance of hydroxyproline

  • We also demonstrated that cav-1 markedly ameliorated bleomycin (BLM)-induced pulmonary fibrosis, as indicated by histological analysis, hydroxyproline content, and immunoblot analysis [1].
  • Urinary hydroxyproline (r = 0.29, P less than 0.001), an index of bone resorption, and serum alkaline phosphatase (r = 0.31, P less than 0.001), an index of bone formation, also increased with age and these increases correlated with increases in serum BGP (r = 0.39, P less than 0.001 and r = 0.43, P less than 0.001, respectively) [2].
  • Collagen synthesis, as measured by the formation of labeled protein-bound hydroxyproline, occurred in granulomas isolated from fibrotic livers [3].
  • In those animals with normal RV pressures at death, hypertrophy had regressed and hydroxyproline concentration was comparable to that of nonbanded and banded animals; Active and passive mechanical function remained normal [4].
  • Compared to rats inoculated on day 1 after birth, rats inoculated at 4 days of age developed consistently more osteoproliferative bone tumors that often were associated with hypercalcemia, increased serum alkaline phosphatase, and elevated urinary hydroxyproline [5].
 

Psychiatry related information on hydroxyproline

 

High impact information on hydroxyproline

 

Chemical compound and disease context of hydroxyproline

 

Biological context of hydroxyproline

 

Anatomical context of hydroxyproline

 

Associations of hydroxyproline with other chemical compounds

  • Relaxin also restored bleomycin-induced collagen accumulation, as measured by lung hydroxyproline content, to normal levels (P < 0.05) [28].
  • The estimated molecular weights of the two glycopeptides by sodium dodecyl sulfate-acrylamide gel electrophoresis were found to be 62,000 and 36,000 and both were found to contain hydroxyproline and relatively high amount of glycine (11 and 15 per cent, respectively) [29].
  • Similar concentrations of tryptase resulted in a 2.5-fold increase in collagen synthesis as determined both by incorporation of [3H]proline into collagen, and by assay of hydroxyproline concentrations in the supernatants [30].
  • O-linked arabinosylation of the hydroxyproline residues of extensin occurs in cis-cisternae, and glycosylated molecules pass through all cisternae before they are packaged into secretory vesicles in the monensin-sensitive, trans-Golgi network [31].
  • MEASUREMENTS: Bone mineral density of the spine, hip, total body, and forearm; serum total alkaline phosphatase and serum osteocalcin levels at 6-month intervals; and 24-hour urine creatinine and hydroxyproline excretion at baseline, 12 months, and 42 months [32].
 

Gene context of hydroxyproline

  • RESULTS: Smad7-overexpressing BDL rats displayed reduced collagen and alpha-SMA expression and reduced hydroxyproline content in the liver, when compared with animals administered AdLacZ [33].
  • Two dpy-18 mutant strains were shown to have null alleles for phy-1 and to have a reduced hydroxyproline content in their exoskeleton collagens [34].
  • Collagen synthesis was impeded as well, with the wounds of MCP-1(-/-) mice containing significantly less hydroxyproline than those of control mice (25 +/- 3 versus 50 +/- 8 microg/wound at day 5, P < 0.0001) [35].
  • Hepatic granulomas in Stat6-deficient mice were composed of predominantly mononuclear cells with very sparse appearance of eosinophils, and their diminished size was accompanied by decreased amounts of liver hydroxyproline content as a measure of collagen deposition [36].
  • Vitamin D metabolites, sex hormone binding globulin (SHBG), PTH(1-84), osteocalcin, alkaline phosphatase, and hydroxyproline and calcium excretion in 2 h fasting urine were measured [37].
 

Analytical, diagnostic and therapeutic context of hydroxyproline

References

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  20. Hydroxyproline and passive stiffness of pressure-induced hypertrophied kitten myocardium. Williams, J.F., Potter, R.D., Hern, D.L., Mathew, B., Deiss, W.P. J. Clin. Invest. (1982) [Pubmed]
  21. Treatment of osteoporosis of ageing with 1alpha-hydroxycholecalciferol. Lund, B., Hjorth, L., Kjaer, I., Reimann, I., Friis, T., Andersen, R.B., Sorensen, O.H. Lancet (1975) [Pubmed]
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  27. Effect of SQ 14225, an inhibitor of angiotensin I-converting enzyme, on the granulomatous response to Schistosoma mansoni eggs in mice. Weinstock, J.V., Ehrinpreis, M.N., Boros, D.L., Gee, J.B. J. Clin. Invest. (1981) [Pubmed]
  28. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. Unemori, E.N., Pickford, L.B., Salles, A.L., Piercy, C.E., Grove, B.H., Erikson, M.E., Amento, E.P. J. Clin. Invest. (1996) [Pubmed]
  29. Isolation and characterization of two hydroxyproline-containing glycoproteins from normal animal lung lavage and lamellar bodies. Bhattacharyya, S.N., Passero, M.A., DiAugustine, R.P., Lynn, W.S. J. Clin. Invest. (1975) [Pubmed]
  30. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. Cairns, J.A., Walls, A.F. J. Clin. Invest. (1997) [Pubmed]
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  33. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Dooley, S., Hamzavi, J., Breitkopf, K., Wiercinska, E., Said, H.M., Lorenzen, J., Ten Dijke, P., Gressner, A.M. Gastroenterology (2003) [Pubmed]
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