Gene Review:
Bglap - bone gamma-carboxyglutamate (gla) protein
Rattus norvegicus
Synonyms:
BGP, Bglap2, Bgp, Bgpr, Bgpra, ...
- The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors. Pan, L.C., Price, P.A. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein are decreased in streptozocin-induced diabetes. Possible marker for diabetic osteopenia. Ishida, H., Seino, Y., Taminato, T., Usami, M., Takeshita, N., Seino, Y., Tsutsumi, C., Moriuchi, S., Akiyama, Y., Hara, K. Diabetes (1988)
- Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells. Theofan, G., Price, P.A. Mol. Endocrinol. (1989)
- 1,25-Dihydroxyvitamin D3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry. Jowell, P.S., Epstein, S., Fallon, M.D., Reinhardt, T.A., Ismail, F. Endocrinology (1987)
- Vitamin K-dependent carboxylase in skin. de Boer-van den Berg, M.A., Verstijnen, C.P., Vermeer, C. J. Invest. Dermatol. (1986)
- Structural requirements for parathyroid hormone action in mature bone. Effects on release of cyclic adenosine monophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters. Calvo, M.S., Fryer, M.J., Laakso, K.J., Nissenson, R.A., Price, P.A., Murray, T.M., Heath, H. J. Clin. Invest. (1985)
- Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. Celeste, A.J., Rosen, V., Buecker, J.L., Kriz, R., Wang, E.A., Wozney, J.M. EMBO J. (1986)
- Excessive mineralization with growth plate closure in rats on chronic warfarin treatment. Price, P.A., Williamson, M.K., Haba, T., Dell, R.B., Jee, W.S. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Retinoic acid and glucocorticoids enhance the effect of 1,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid protein synthesis by rat osteosarcoma cells. Nishimoto, S.K., Salka, C., Nimni, M.E. J. Bone Miner. Res. (1987)
- The effect of transcriptional inhibitors on the bone gamma-carboxyglutamic acid protein response to 1,25-dihydroxyvitamin D3 in osteosarcoma cells. Pan, L.C., Price, P.A. J. Biol. Chem. (1984)
- Sequence of the precursor to rat bone gamma-carboxyglutamic acid protein that accumulates in warfarin-treated osteosarcoma cells. Pan, L.C., Williamson, M.K., Price, P.A. J. Biol. Chem. (1985)
- Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism. Nanes, M.S., Rubin, J., Titus, L., Hendy, G.N., Catherwood, B. Endocrinology (1991)
- Molecular structure of the rat bone Gla protein gene and identification of putative regulatory elements. Theofan, G., Haberstroh, L.M., Price, P.A. DNA (1989)
- The testosterone mimetic properties of icariin. Zhang, Z.B., Yang, Q.T. Asian J. Androl. (2006)
- 1,25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually exclusive expression of vitamin K-dependent bone proteins by clonal osteoblastic cell lines. Fraser, J.D., Otawara, Y., Price, P.A. J. Biol. Chem. (1988)
- Developmental appearance of matrix GLA protein during calcification in the rat. Otawara, Y., Price, P.A. J. Biol. Chem. (1986)
- A comparative immunocytochemical study on the subcellular distributions of 44 kDa bone phosphoprotein and bone gamma-carboxyglutamic acid (Gla)-containing protein in osteoblasts. Mark, M.P., Prince, C.W., Gay, S., Austin, R.L., Bhown, M., Finkelman, R.D., Butler, W.T. J. Bone Miner. Res. (1987)
- The effect of aging on bone formation in porous hydroxyapatite: biochemical and histological analysis. Inoue, K., Ohgushi, H., Yoshikawa, T., Okumura, M., Sempuku, T., Tamai, S., Dohi, Y. J. Bone Miner. Res. (1997)
- Rapid and sensitive method of quantitation of bone gla protein mRNA using competitive polymerase chain reaction. Araki, N., Robinson, F.D., Nishimoto, S.K. J. Bone Miner. Res. (1993)
- Tumor necrosis factor alpha decreases 1,25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells. Mayur, N., Lewis, S., Catherwood, B.D., Nanes, M.S. J. Bone Miner. Res. (1993)
- Interferon-gamma inhibits 1,25-dihydroxyvitamin D3-stimulated synthesis of bone GLA protein in rat osteosarcoma cells by a pretranslational mechanism. Nanes, M.S., Rubin, J., Titus, L., Hendy, G.N., Catherwood, B.D. Endocrinology (1990)
- Distinct responses of different populations of bone cells to mechanical stress. Mikuni-Takagaki, Y., Suzuki, Y., Kawase, T., Saito, S. Endocrinology (1996)
- Interferon-gamma causes loss of bone volume in vivo and fails to ameliorate cyclosporin A-induced osteopenia. Mann, G.N., Jacobs, T.W., Buchinsky, F.J., Armstrong, E.C., Li, M., Ke, H.Z., Ma, Y.F., Jee, W.S., Epstein, S. Endocrinology (1994)
- The effect of a new vitamin D analog, 22-oxa-1 alpha,25(OH)2D3, on bone mineral metabolism in normal male rats. Takizawa, M., Fallon, M., Stein, B., Epstein, S. Calcif. Tissue Int. (1992)
- Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis. Barone, L.M., Owen, T.A., Tassinari, M.S., Bortell, R., Stein, G.S., Lian, J.B. J. Cell. Biochem. (1991)
- Heterogeneous pattern of gene expression in cloned cell lines established from a rat transplantable osteosarcoma lung metastatic nodule. Honoki, K., Mori, T., Tsutsumi, M., Tsujiuchi, T., Kido, A., Morishita, T., Miyauchi, Y., Dohi, Y., Mii, Y., Tamai, S., Konishi, Y. Cancer Lett. (1998)
- The identification of matrix Gla protein in cartilage. Hale, J.E., Fraser, J.D., Price, P.A. J. Biol. Chem. (1988)
- Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cells. Evidence for an intracellular precursor. Nishimoto, S.K., Price, P.A. J. Biol. Chem. (1980)
- Influence of age on cyclosporin A-induced alterations in bone mineral metabolism in the rat in vivo. Katz, I., Li, M., Joffe, I., Stein, B., Jacobs, T., Liang, X.G., Ke, H.Z., Jee, W., Epstein, S. J. Bone Miner. Res. (1994)