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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A novel effect of EGF on mRNA stability.

Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA). PMA elevates EGF receptor mRNA levels in human KB epidermoid carcinoma cells, but does not significantly affect the half-life of this mRNA when its decay is examined after the addition of actinomycin D. In contrast, EGF greatly prolongs the half-life of EGF receptor mRNA suggesting a possible mechanism for the stimulatory effect of EGF on EGF receptor mRNA levels. EGF also stabilizes beta-tubulin and beta-actin mRNAs but has very little effect on the degradation of total mRNA.[1]


  1. A novel effect of EGF on mRNA stability. Jinno, Y., Merlino, G.T., Pastan, I. Nucleic Acids Res. (1988) [Pubmed]
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