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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound.

AS-101 (ammonium trichloro[dioxoethylene-O,O'-]tellurate) is a newly developed synthetic compound with immunomodulating properties and minimal toxicity. We evaluated the effects of AS-101 on various parameters of the activation and function of immunocompetent cells. AS-101 induced IL-2 receptor expression, IL-2 production and proliferation by human and mouse lymphocytes in vitro and enhanced the production colony- stimulating factor ( CSF) by mouse spleen cells. In vivo treatment of Balb/c mice with AS-101 caused a significantly increased production of IL-2 and CSF in vitro in the presence of mitogen. When administered systemically to mice, AS-101 mediated antitumor effects in vivo. These results suggest that AS-101 is an active biological response modifier, which might have potential use in the treatment of conditions such as malignancy, AIDS and some types of immune deficiency.[1]

References

  1. The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound. Sredni, B., Caspi, R.R., Lustig, S., Klein, A., Kalechman, Y., Danziger, Y., Ben Ya'akov, M., Tamari, T., Shalit, F., Albeck, M. Nat. Immun. Cell Growth Regul. (1988) [Pubmed]
 
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