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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells.

The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn ( B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient. Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.[1]


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