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Disease relevance of Eimeria


High impact information on Eimeria

  • Purine metabolism in the protozoan parasite Eimeria tenella [6].
  • Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima [7].
  • The molecular target of Compound 1 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella [8].
  • The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (Compound 1) inhibits the growth of Eimeria spp. both in vitro and in vivo [8].
  • Apple domains are composed of six spacely conserved cysteine residues which form disulfide bridges and are also present in micronemal proteins from two closely related apicomplexan parasites, Sarcocystis muris and Eimeria species, and several mammalian serum proteins, including kallikrein [9].

Chemical compound and disease context of Eimeria


Biological context of Eimeria


Anatomical context of Eimeria


Associations of Eimeria with chemical compounds

  • A metabolic pathway responsible for the biosynthesis and utilization of mannitol is present in the seven species of Eimeria that infect chickens, but is not in the avian host [24].
  • A glycoprotein unique to the cytoplasm of the unsporulated oocyst of Eimeria tenella has been purified and partially characterized [25].
  • IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid [26].
  • Mycophenolic acid (MA) was demonstrated to be an effective inhibitor of the growth of the intracellular parasitic protozoan Eimeria tenella in tissue culture and guanine was shown to reverse this inhibition as expected for an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC [26].
  • Of these compounds 2-nitro- and 3-nitro- but not 4-nitropyridinecarboxamides were found to be active against Eimeria tenella [27].

Gene context of Eimeria

  • Since EtS3a expression is also developmentally regulated, we suggest that this gene product is a functional homologue of fte-1, cyc-07 and MFT1 and an important molecule regulating the development of Eimeria tenella [17].
  • Neutralisation of endogenously produced IFN-gamma has shown that this cytokine limits oocyst production in either primary or secondary infections depending on the species of Eimeria [28].
  • Identification of a fibronectin-like molecule on Eimeria tenella [29].
  • In vivo expression profiles of cytokine and iNOS mRNAs in rats infected with Eimeria separata [30].
  • Passive immunization against somatostatin increases resistance to Eimeria vermiformis infection in susceptible mice [31].

Analytical, diagnostic and therapeutic context of Eimeria


  1. Eimeria tenella infection induces local gamma interferon production and intestinal lymphocyte subpopulation changes. Yun, C.H., Lillehoj, H.S., Choi, K.D. Infect. Immun. (2000) [Pubmed]
  2. A comparison of the effects of infection with Eimeria maxima and dietary restriction on weight gain, plasma metabolites and liver glycogen in the immature fowl, Gallus domesticus. Chapman, H.D., Fernandes, D.L., Davison, T.F. Parasitology (1982) [Pubmed]
  3. Effect of lactose and Lactobacillus acidophilus on the colonization of Salmonella enteritidis in chicks concurrently infected with Eimeria tenella. Qin, Z.R., Fukata, T., Baba, E., Arakawa, A. Avian Dis. (1995) [Pubmed]
  4. Evaluation of a mixture of trimethoprim and sulphaquinoxaline for the treatment of bacterial and coccidial diseases of poultry. White, G., Williams, R.B. Vet. Rec. (1983) [Pubmed]
  5. Anticoccidial activity of combinations of narasin and nicarbazin. Long, P.L., Johnson, J., McKenzie, M.E. Poult. Sci. (1988) [Pubmed]
  6. Purine metabolism in the protozoan parasite Eimeria tenella. Wang, C.C., Simashkevich, P.M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  7. Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. Rothwell, L., Young, J.R., Zoorob, R., Whittaker, C.A., Hesketh, P., Archer, A., Smith, A.L., Kaiser, P. J. Immunol. (2004) [Pubmed]
  8. Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target. Gurnett, A.M., Liberator, P.A., Dulski, P.M., Salowe, S.P., Donald, R.G., Anderson, J.W., Wiltsie, J., Diaz, C.A., Harris, G., Chang, B., Darkin-Rattray, S.J., Nare, B., Crumley, T., Blum, P.S., Misura, A.S., Tamas, T., Sardana, M.K., Yuan, J., Biftu, T., Schmatz, D.M. J. Biol. Chem. (2002) [Pubmed]
  9. The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. Brecht, S., Carruthers, V.B., Ferguson, D.J., Giddings, O.K., Wang, G., Jakle, U., Harper, J.M., Sibley, L.D., Soldati, D. J. Biol. Chem. (2001) [Pubmed]
  10. Eimeria acervulina infection in chicks fed cobalt in the presence or absence of excess dietary methionine. Southern, L.L., Baker, D.H. J. Nutr. (1982) [Pubmed]
  11. The use of vitamin K deficient diets in the screening and evaluation of anticoccidial drugs. Ryley, J.F., Hardman, L. Parasitology (1978) [Pubmed]
  12. Sensitivity of field isolates of Eimeria to monensin following the use of a coccidiosis vaccine in broiler chickens. Chapman, H.D. Poult. Sci. (1994) [Pubmed]
  13. Efficacy of lasalocid sodium against coccidiosis (Eimeria zuernii and Eimeria bovis) in calves. Stromberg, B.E., Schlotthauer, J.C., Armstrong, B.D., Brandt, W.E., Liss, C. Am. J. Vet. Res. (1982) [Pubmed]
  14. Chemoprophylaxis of coccidiosis in lambs with a single oral dose of toltrazuril. Gjerde, B., Helle, O. Vet. Parasitol. (1991) [Pubmed]
  15. Murine major histocompatibility complex and immune response to Eimeria falciformis. Mahrt, J.L., Shi, Y.F. Infect. Immun. (1988) [Pubmed]
  16. Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells. Joysey, H.S., Wakelin, D., Rose, M.E. Infect. Immun. (1988) [Pubmed]
  17. Eimeria tenella: cloning and characterization of cDNA encoding a S3a ribosomal protein. Ouarzane, M., Labbé, M., Péry, P. Gene (1998) [Pubmed]
  18. Total intestinal absorption of glucose and L-methionine in broilers infected with Eimeria acervulina, E. mivati, E. maxima or E. brunetti. Ruff, M.D., Wilkins, G.C. Parasitology (1980) [Pubmed]
  19. Major histocompatibility (B) complex effects on acquired immunity to cecal coccidiosis. Clare, R.A., Strout, R.G., Taylor, R.L., Collins, W.M., Briles, W.E. Immunogenetics (1985) [Pubmed]
  20. Purification and characterisation of a serine-type protease from Eimeria tenella oocysts. Michalski, W.P., Crooks, J.K., Prowse, S.J. Int. J. Parasitol. (1994) [Pubmed]
  21. The large-scale preparation of purified sporozoites of Eimeria spp. by metrizamide density-gradient centrifugation. Wisher, M.H., Rose, M.E. Parasitology (1984) [Pubmed]
  22. Chicken tumor necrosis-like factor. I. In vitro production by macrophages stimulated with Eimeria tenella or bacterial lipopolysaccharide. Zhang, S., Lillehoj, H.S., Ruff, M.D. Poult. Sci. (1995) [Pubmed]
  23. A new method for purification of Eimeria tenella merozoites. Xie, M.Q., Gilbert, J.M., Fuller, A.L., McDougald, L.R. Parasitol. Res. (1990) [Pubmed]
  24. Molecular cloning and functional expression of mannitol-1-phosphatase from the apicomplexan parasite Eimeria tenella. Liberator, P., Anderson, J., Feiglin, M., Sardana, M., Griffin, P., Schmatz, D., Myers, R.W. J. Biol. Chem. (1998) [Pubmed]
  25. Studies of a glycoprotein in the oocysts of Eimeria tenella. Stotish, R.L., Wang, C.C., Hichens, M., VandenHeuvel, W.J., Gale, P. J. Biol. Chem. (1976) [Pubmed]
  26. IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid. Hupe, D.J., Azzolina, B.A., Behrens, N.D. J. Biol. Chem. (1986) [Pubmed]
  27. Studies on anticoccidial agents. 11. Synthesis and anticoccidial activity of nitropyridinecarboxamides and derivatives. Morisawa, Y., Kataoka, M., Kitano, N. J. Med. Chem. (1977) [Pubmed]
  28. Cytokines and immunological control of Eimeria spp. Ovington, K.S., Alleva, L.M., Kerr, E.A. Int. J. Parasitol. (1995) [Pubmed]
  29. Identification of a fibronectin-like molecule on Eimeria tenella. Lopez-Bernad, F., Del Cacho, E., Gallego, M., Quilez, J., Sanchez-Acedo, C. Parasitology (1996) [Pubmed]
  30. In vivo expression profiles of cytokine and iNOS mRNAs in rats infected with Eimeria separata. Shi, M.Q., Hirzmann, J., Dafa'alla, T.H., Zahner, H. Vet. Parasitol. (2001) [Pubmed]
  31. Passive immunization against somatostatin increases resistance to Eimeria vermiformis infection in susceptible mice. Yun, C.H., Estrada, A., Gajadhar, A.A., Redmond, M.J., Laarveld, B. Comp. Immunol. Microbiol. Infect. Dis. (1996) [Pubmed]
  32. A role for coccidian cGMP-dependent protein kinase in motility and invasion. Wiersma, H.I., Galuska, S.E., Tomley, F.M., Sibley, L.D., Liberator, P.A., Donald, R.G. Int. J. Parasitol. (2004) [Pubmed]
  33. Adjuvant effects of IL-1beta, IL-2, IL-8, IL-15, IFN-alpha, IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina. Min, W., Lillehoj, H.S., Burnside, J., Weining, K.C., Staeheli, P., Zhu, J.J. Vaccine (2001) [Pubmed]
  34. Diclazuril, a new broad spectrum anticoccidial drug in chickens. 1. Dose titration studies and pilot floor pen trials. Vanparijs, O., Marsboom, R., Desplenter, L. Poult. Sci. (1989) [Pubmed]
  35. Changes in carotenoid and vitamin A levels in young turkeys infected with Eimeria meleagrimitis or E. adenoeides. Augustine, P.C., Ruff, M.D. Avian Dis. (1983) [Pubmed]
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