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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Frontal midline theta activity and platelet MAO in human subjects.

The distinctive theta rhythm that appears at the frontal midline during the performance of mental tasks has been designated as frontal midline theta (Fm theta). Fm theta shows individual differences and seems to be related to certain personality traits. In several studies, it has been indicated that low platelet monoamine oxidase (MAO) activity is also associated with certain personality traits. In the present study, we found a negative correlation between the appearance of Fm theta and platelet MAO activity. Subjects with marked extroversion show a high amount of Fm theta and low MAO activity. It is therefore suggested that Fm theta, an electrophysiological marker, may be useful in the investigation of monoamine functions in the central nervous system (CNS) by way of platelet MAO activity, a biochemical marker.[1]


  1. Frontal midline theta activity and platelet MAO in human subjects. Hashimoto, M., Mukasa, H., Yamada, S., Nakamura, J., Inanaga, K. Biol. Psychiatry (1988) [Pubmed]
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