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MeSH Review

Extraversion (Psychology)

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Disease relevance of Extraversion (Psychology)


Psychiatry related information on Extraversion (Psychology)


High impact information on Extraversion (Psychology)


Chemical compound and disease context of Extraversion (Psychology)

  • These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (ie low extraversion and high neuroticism) is unlikely to be wholly accounted for by the well-studied rs4680 ('val/met') polymorphism [12].
  • Extraversion as a modifying factor in catecholamine and behavioral responses to ethanol [13].
  • It was found that Diazepam decreased feelings of activation and extraversion and increased calmness [14].
  • The scale intercorrelation matrix yielded a three-factor solution with Factor 1 reflecting Neuroticism; Factor 2 Aggressiveness; and Factor 3 reflecting Extraversion [15].
  • This paper analyses the influence of and possible interaction between chronotype (Morning-types, Neither-types and Evening-types) and personality dimensions (neuroticism, extroversion and psychoticism) in the daily consumption of alcohol and psychostimulants (nicotine and caffeine) [16].

Biological context of Extraversion (Psychology)


Anatomical context of Extraversion (Psychology)


Gene context of Extraversion (Psychology)

  • Here, we examined the association between the dopamine D2 receptor (DRD2) TaqI A polymorphism and two other personality traits, neuroticism-anxiety and agentic extraversion [22].
  • Subjects with marked extroversion show a high amount of Fm theta and low MAO activity [23].
  • RESULTS: Task-oriented coping showed a positive correlation with extraversion and frustration tolerance [24].
  • In general, higher scores on the NEO dimensions of Extraversion and Openness predicted greater ACTH responses [25].
  • CONCLUSION: Some personality traits such as extraversion and frustration tolerance are significantly related to task-oriented coping, and psychopathological personality traits such as neuroticism are associated with emotional-oriented coping in major depressive disorder [24].

Analytical, diagnostic and therapeutic context of Extraversion (Psychology)

  • Joint factor analysis of RCS, PDQ-4+, and B5M items also resulted in 6 factors: Self-Centeredly Exploitative, Poor Ego Resiliency, Extraversion, Task Conscientiousness, Openness to Ideas, and Emotional and Expressive Constriction [26].


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  3. DRD4 promoter SNPs and gender effects on Extraversion in African Americans. Bookman, E.B., Taylor, R.E., Adams-Campbell, L., Kittles, R.A. Mol. Psychiatry (2002) [Pubmed]
  4. Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram. Liechti, M.E., Baumann, C., Gamma, A., Vollenweider, F.X. Neuropsychopharmacology (2000) [Pubmed]
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  10. Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA). Frei, E., Gamma, A., Pascual-Marqui, R., Lehmann, D., Hell, D., Vollenweider, F.X. Human brain mapping. (2001) [Pubmed]
  11. HPA axis function and temperament in depression: a negative report. Roy, A. Biol. Psychiatry (1996) [Pubmed]
  12. COMT polymorphisms and anxiety-related personality traits. Stein, M.B., Fallin, M.D., Schork, N.J., Gelernter, J. Neuropsychopharmacology (2005) [Pubmed]
  13. Extraversion as a modifying factor in catecholamine and behavioral responses to ethanol. Netter, P., Vogel, W., Rammsayer, T. Psychopharmacology (Berl.) (1994) [Pubmed]
  14. Mood effects of diazepam and caffeine. Svensson, E., Persson, L.O., Sjöberg, L. Psychopharmacology (Berl.) (1980) [Pubmed]
  15. Swedish universities Scales of Personality (SSP): construction, internal consistency and normative data. Gustavsson, J.P., Bergman, H., Edman, G., Ekselius, L., von Knorring, L., Linder, J. Acta psychiatrica Scandinavica. (2000) [Pubmed]
  16. Chronotype and personality factors in the daily consumption of alcohol and psychostimulants. Adan, A. Addiction (1994) [Pubmed]
  17. The molecular genetic architecture of human personality: beyond self-report questionnaires. Ebstein, R.P. Mol. Psychiatry (2006) [Pubmed]
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  19. Five-year follow-up of cosmetic rhinoplasty. Ercolani, M., Baldaro, B., Rossi, N., Trombini, G. Journal of psychosomatic research. (1999) [Pubmed]
  20. Personality and tonic cardiovascular, neuroendocrine, and immune parameters. Miller, G.E., Cohen, S., Rabin, B.S., Skoner, D.P., Doyle, W.J. Brain Behav. Immun. (1999) [Pubmed]
  21. Potential psychosocial mechanisms linking depression to immune function in elderly subjects. Bouhuys, A.L., Flentge, F., Oldehinkel, A.J., van den Berg, M.D. Psychiatry research. (2004) [Pubmed]
  22. Sexually dimorphic link between dopamine D2 receptor gene and neuroticism-anxiety. Wacker, J., Reuter, M., Hennig, J., Stemmler, G. Neuroreport (2005) [Pubmed]
  23. Frontal midline theta activity and platelet MAO in human subjects. Hashimoto, M., Mukasa, H., Yamada, S., Nakamura, J., Inanaga, K. Biol. Psychiatry (1988) [Pubmed]
  24. Relationship between stress coping and personality in patients with major depressive disorder. Uehara, T., Sakado, K., Sakado, M., Sato, T., Someya, T. Psychotherapy and psychosomatics. (1999) [Pubmed]
  25. Comparison of HPA axis hormonal responses to naloxone vs psychologically-induced stress. Oswald, L.M., Mathena, J.R., Wand, G.S. Psychoneuroendocrinology (2004) [Pubmed]
  26. Correspondence among observer ratings of Rorschach, Big Five Model, and DSM-IV personality disorder constructs. Mihura, J.L., Meyer, G.J., Bel-Bahar, T., Gunderson, J. Journal of personality assessment. (2003) [Pubmed]
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