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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Differential mechanisms of feeding modulation induced by amino sugars in rats.

The present study examined and compared the effects of N-acetylglucosamine and 1-deoxy-N-acetylglucosamine on feeding behavior with those of glucosamine and 1-deoxyglucosamine. Infusion of 12 mu mole N-acetylglucosamine and 24 mu mole 1-deoxy-N-acetylglucosamine into the rat third cerebroventricle did not affect the feeding behavior. However, oral administration of 1200 mumol N-acetylglucosamine elicited feeding and 2400 mumol 1-deoxy-N-acetylglucosamine markedly suppressed feeding. These effects were abolished by truncal vagotomy. Both glucosamine and 1-deoxyglucosamine affected feeding by intra-third cerebroventricular and oral administration. These findings indicate that N-acetyl amino sugars modulate feeding behavior peripherally through the vagal afferent nerve.[1]


  1. Differential mechanisms of feeding modulation induced by amino sugars in rats. Okabe, Y., Sakata, T., Fujimoto, K., Kurata, K., Yoshimatsu, H., Ueda, K. Proc. Soc. Exp. Biol. Med. (1988) [Pubmed]
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