Disease relevance of Vagotomy, Truncal

• The frequency and severity of diarrhoea were compared in 102 randomly selected men 10 or more years after truncal vagotomy and pyloroplasty (TVP) and a control group of 62 men taking long-term maintenance cimetidine treatment 2 or more years after healing of duodenal ulcer [1].
• In two sets of dogs with gastric and pancreatic fistulas, we studied the effect of atropine on the pancreatic secretory response to intravenous secretin before and after cutting the extrinsic nerves of the pancreas, i.e., celiac and superior mesenteric ganglionectomy alone or truncal vagotomy plus celiac and superior mesenteric ganglionectomy [2].
• The effects of truncal vagotomy after administration of N-methyl-N'-nitro-N-nitrosoguanidine on the incidence and number of gastric carcinomas and gastric acid secretion, gastrin secretion, antral pH, and duodenal reflux were investigated in inbred Wistar rats [3].
• Hypoglycemia induced a brisk rise in plasma pancreatic polypeptide (hPP) concentrations in healthy subjects (maximum concentration 1563 +/- 245 pg/ml) whereas in none of the postvagotomy subjects was there a significant change in hPP concentrations, indicative of completeness of the truncal vagotomy [4].
• Erythromycin may have a role in the treatment of gastric stasis following oesophagectomy or truncal vagotomy [5].

Psychiatry related information on Vagotomy, Truncal

• The suppression of colonic motor activity was not blocked by bilateral truncal vagotomy or intravenous administration of phentolamine, an alpha-receptor antagonist, and propranolol, a beta-receptor antagonist [6].

High impact information on Vagotomy, Truncal

• Truncal vagotomy and administration of hexamethonium significantly reduced nonadrenergic, noncholinergic relaxation, the catalytic activity of NOS, the number of NOS-immunoreactive cells, and the density of NOS-immunoreactive bands and NOS mRNA bands obtained from gastric tissue [7].
• The significant release of these hormones was suppressed by pretreatment with atropine and completely eliminated by a 5-hydroxytryptamine 3 receptor antagonist and truncal vagotomy [8].
• Truncal vagotomy prevented the central inhibitory action of TRH but not that of CGRP, whereas noradrenergic blockade prevented the central inhibitory action of CGRP but not that of TRH [9].
• Ganglionic blockade with chlorisondamine and truncal vagotomy abolished the stimulatory effect of somatostatin-28 while bretylium, naloxone, indomethacin, and adrenalectomy did not [10].
• In the 6 patients with truncal vagotomy, plasma CCK and gallbladder responses to intraduodenal fat were significantly delayed compared to normal subjects [11].

Chemical compound and disease context of Vagotomy, Truncal

• Jejunal inhibition of gastric acid secretion induced by hypertonic glucose in duodenal ulcer patients before and after truncal vagotomy [12].
• The effects of truncal vagotomy and parietal cell vagotomy on gastric acid secretion and plasma gastrin and pancreatic polypeptide release were studied in 28 duodenal ulcer patients under basal conditions and after modified sham feeding and infusion of pentagastrin (2 micrograms/kg/h) [13].
• Lithium fluxes were lowest in the asymptomatic postoperative patients (0.149 +/- 0.028 mmol Li+/15 min), but were not significantly different to the measured fluxes in patients with a duodenal ulcer before treatment (0.160 +/- 0.020 mmol Li+/15 min) or a recurrent ulcer after truncal vagotomy and drainage (0.169 +/- 0.022 mmol Li+/15 min) (SEM) [14].
• Bile acid and lysolecithin concentrations in the stomach in patients with duodenal ulcer before operation and after treatment by highly selective vagotomy, partial gastrectomy, or truncal vagotomy and drainage [15].
• Dose-response studies of acid secretion after administration of tetragastrin. Studies in duodenal ulcer patients before and after highly selective vagotomy, hemigastrectomy and truncal vagotomy plus antrectomy [16].

Biological context of Vagotomy, Truncal

• Inhibition of gastric emptying induced by central administration of CRF was completely abolished by pretreatment of the animals with either the ganglionic blocking agent chlorisondamine or the opioid antagonist naloxone, or by noradrenergic blockade with bretylium, but not by truncal vagotomy [17].
• Kinetics of intra operative pH of the canine corpus fundal mucosa before and after truncal vagotomy [18].
• In contrast to the effect on ornithine decarboxylase activity, the truncal vagotomies had no effect on apoptosis in rats with lesions [19].
• After truncal vagotomy, while motilin release and the intestinal motility pattern remained unaltered, the phase III associated cyclical increases of PP disappeared [20].

Anatomical context of Vagotomy, Truncal

• After subdiaphragmatic truncal vagotomy, CGRP did not exhibit the inhibitory effect on gastric acid secretion stimulated by pentagastrin [21].
• Lithium fluxes across the gastric mucosa after truncal vagotomy and drainage--an objective assessment of mucosal injury [14].
• In another 15 patients receiving epidural blockade, the vagus nerve was blocked by injection of local anaesthetics or by truncal vagotomy, and their cortisol response to gastrectomy was compared with the other two groups [22].
• The c-fos expression in all these brain nuclei was blocked by truncal vagotomy as well as by perivagal capsaicin treatment, suggesting that vagal afferent pathways may mediate this response [23].
• Subsequent truncal vagotomy had no effect on CCK8-induced relaxation in rats with perivagal capsaicin treatment, but completely abolished CCK8-induced relaxation in rats with capsaicin treatment of the celiac ganglia [24].

Associations of Vagotomy, Truncal with chemical compounds

• Truncal vagotomy alone significantly decreased the incremental protein response to low (0.12, 0.37, and 1.1 mmol/h) but not high loads of tryptophan [25].
• In animals with truncal vagotomy, the protective effect of 16,16-dmPGE2 or 30% ethanol was not observed [26].
• Studies have been performed on man after truncal vagotomy to ascertain the effect of 1.2 mg of atropine sulfate on basal and postprandial immunoreactive gastrin [27].
• The studies were repeated after a truncal vagotomy that abolished acid secretion in response to 2-deoxyglucose [28].
• Between January, 1969, and December, 1973, 2058 truncal vagotomies were performed in the Merseyside Regional Health Authority area [29].

Gene context of Vagotomy, Truncal

• Pancreatico-duodenectomy or antrectomy with or without duodenal exclusion or antrectomy with truncal vagotomy did not significantly change the basal release of CCK or the GRP-induced CCK release [30].
• For this reason, we studied the effect of truncal vagotomy on the suppression of feeding induced by amylin [31].
• ANF-evoked protein secretion was not inhibited by truncal vagotomy, atropine, or Nomega-nitro-l-arginine methyl ester administration [32].
• After truncal vagotomy, basal pancreatic polypeptide concentration was decreased and modified sham feeding-induced pancreatic polypeptide increment was completely eliminated [13].
• The effects of truncal vagotomy on gastrin cell and somatostatin cell populations and circulating hormone levels were studied in rats [33].

Analytical, diagnostic and therapeutic context of Vagotomy, Truncal

• Ganglionectomy, truncal vagotomy, and atropine did not alter basal or tryptophan-stimulated levels of plasma cholecystokininlike immunoreactivity [25].
• The effect of vagotomy and gastric resection on insulin secretion was examined by the glucagon stimulated C-peptide test in gastrectomy patients (n = 11) without truncal vagotomy and in total gastrectomy patients (n = 10) with truncal vagotomy [34].
• Gastric resection without truncal vagotomy was followed by a higher increase (48%) in serum C-peptide concentration caused by glucagon stimulation than total gastrectomy with truncal vagotomy (13%) [34].
• An oral glucose tolerance test was performed in patients who had undergone truncal vagotomy and pyloroplasty, bilateral selective vagotomy and pyloroplasty, or highly selective vagotomy without a drainage procedure at least six months earlier [35].
• The changes in the difference in the transmucosal potential of the stomach, in the ion flux of the mucosa and the prostaglandin content of the mucosa were studied after pyloric ligation combined with truncal vagotomy in rats [36].

References