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Richter, J. et al.

Thymidylate synthase gene of herpesvirus ateles.

The putative thymidylate synthase ( TS) gene of herpesvirus ateles, a T-lymphotropic tumor virus of New World primates, has a single large open reading frame encoding a polypeptide of 32.9 kilodaltons. The gene is transcribed into an unspliced 2.4-kilobase mRNA that is abundantly expressed late in virus replication. The AT-rich 5' untranslated leader sequence of TS mRNA in herpesvirus ateles-infected cells is remarkable in length (1,184 nucleotides), containing 29 minicistrons; this may indicate a role in translation regulation.[1]

References

Thymidylate synthase gene of herpesvirus ateles. Richter, J., Puchtler, I., Fleckenstein, B. J. Virol. (1988) [Pubmed]

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