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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transforming growth factor alpha inhibits secretion of gastric acid.

Transforming growth factor alpha (TGF-alpha), a protein secreted by transformed cells and related to epidermal growth factor ( EGF), was tested for its effects on gastric acid secretion. Guinea pig gastric mucosae were mounted in Ussing chambers and the rate of acid release was monitored by the pH-stat method. When administered prior to the secretagogue, TGF-alpha prevented the histamine-induced increase in the rate of acid secretion. Similarly, TGF-alpha caused a decrease in the rate of acid release in tissues that had already been stimulated with histamine. These data show that TGF-alpha inhibits gastric acid secretion in a manner similar to EGF and that the two growth factors share at least one physiological action unrelated to their mitogenic properties.[1]


  1. Transforming growth factor alpha inhibits secretion of gastric acid. Rhodes, J.A., Tam, J.P., Finke, U., Saunders, M., Bernanke, J., Silen, W., Murphy, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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