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Gene Review

EGF  -  epidermal growth factor

Sus scrofa

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Disease relevance of EGF


High impact information on EGF


Chemical compound and disease context of EGF

  • During exposure to luminal acid, ex-EGF not only prevented intracellular acidosis but also promoted restitution [8].
  • METHODS: Twenty-four minipigs with surgically induced portal hypertension underwent four consecutive weekly sessions of oesophageal sclerotherapy with 5 ml 1% polidocanol and were concomitantly treated with either a placebo or human recombinant EGF administered subcutaneously [9].
  • Expression of enhanced green fluorescent protein (EGFP) and neomycin resistant (Neo(R)) genes in porcine embryos following nuclear transfer with porcine fetal fibroblasts transfected by retrovirus vector [10].

Biological context of EGF

  • These findings show that EGF mRNA expression is temporally regulated during the cycle and early pregnancy, and this pattern of gene expression may be important during early conceptus development [11].
  • A decrease in the intensity of EGF immunostaining was observed in the late luteal phase [12].
  • The aim of our study was to determine EGF and EGFR immunoexpression in the uterine artery and its branches during the estrous cycle in the pig [12].
  • The highest intensity of EGF and EGFR immunoreaction in endothelial cells of the uterine artery was observed in the follicular phase [12].
  • Epidermal growth factor (EGF) and its receptor (EGFR) are expressed in many tissues, including reproductive organs, and is involved in angiogenesis, embryo implantation and development as well as in proliferation and differentiation of various cells [12].

Anatomical context of EGF


Associations of EGF with chemical compounds

  • Tyrosine kinase inhibitors and cyclooxygenase and lipoxygenase inhibitors reduced pepsinogen secretion and eicosanoid generation induced by EGF [7].
  • Cyclic adenosine monophosphate-induced secretion was also reduced by EGF, although the effect occurred more slowly than in histamine-treated tissues [13].
  • When applied to the luminal (mucosal) gastric surface, EGF inhibited secretion marginally but only at micromolar concentrations [13].
  • The effect of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity of the rat hepatic plasma membrane was studied [2].
  • Epidermal growth factor (EGF) increased EET production in F87V BM-3 cells, which was completely abolished by pretreatment with either 17-ODYA or the phospholipase A2 (PLA2) inhibitor, quinacrine [14].

Physical interactions of EGF

  • Thus, the ability of porcine GCs to bind EGF was changed with differentiation in vivo, while both EGF-binding capacity and mitotic responsiveness were regulated by exposure to FSH in vitro [15].

Enzymatic interactions of EGF


Regulatory relationships of EGF


Other interactions of EGF


Analytical, diagnostic and therapeutic context of EGF


  1. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Schultz, G.S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D.R., Todaro, G.J. Science (1987) [Pubmed]
  2. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Madhukar, B.V., Brewster, D.W., Matsumura, F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro. Akiyama, T., Kadowaki, T., Nishida, E., Kadooka, T., Ogawara, H., Fukami, Y., Sakai, H., Takaku, F., Kasuga, M. J. Biol. Chem. (1986) [Pubmed]
  4. A uterine cell mitogen distinct from epidermal growth factor in porcine uterine luminal fluids: characterization and partial purification. Simmen, R.C., Ko, Y., Liu, X.H., Wilde, M.H., Pope, W.F., Simmen, F.A. Biol. Reprod. (1988) [Pubmed]
  5. Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. Brown, G.L., Curtsinger, L., Brightwell, J.R., Ackerman, D.M., Tobin, G.R., Polk, H.C., George-Nascimento, C., Valenzuela, P., Schultz, G.S. J. Exp. Med. (1986) [Pubmed]
  6. Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Sangild, P.T., Siggers, R.H., Schmidt, M., Elnif, J., Bjornvad, C.R., Thymann, T., Grondahl, M.L., Hansen, A.K., Jensen, S.K., Boye, M., Moelbak, L., Buddington, R.K., Weström, B.R., Holst, J.J., Burrin, D.G. Gastroenterology (2006) [Pubmed]
  7. Epidermal growth factor modulates pepsinogen secretion in guinea pig gastric chief cells. Fiorucci, S., Lanfrancone, L., Santucci, L., Calabro, A., Orsini, B., Federici, B., Morelli, A. Gastroenterology (1996) [Pubmed]
  8. EGF promotes gastric mucosal restitution by activating Na(+)/H(+) exchange of epithelial cells. Yanaka, A., Suzuki, H., Shibahara, T., Matsui, H., Nakahara, A., Tanaka, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  9. Preventive effects of recombinant human epidermal growth factor on the oesophageal epithelium in pigs subjected to sclerotherapy. Juhl, C.O., Vinter-Jensen, L., Jensen, L.S., Dajani, E.Z. European journal of gastroenterology & hepatology. (1995) [Pubmed]
  10. Expression of enhanced green fluorescent protein (EGFP) and neomycin resistant (Neo(R)) genes in porcine embryos following nuclear transfer with porcine fetal fibroblasts transfected by retrovirus vector. Uhm, S.J., Kim, N.H., Kim, T., Chung, H.M., Chung, K.H., Lee, H.T., Chung, K.S. Mol. Reprod. Dev. (2000) [Pubmed]
  11. Characterization of uterine epidermal growth factor during early pregnancy in pigs. Kim, J.G., Vallet, J.L., Christenson, R.K. Domest. Anim. Endocrinol. (2001) [Pubmed]
  12. Epidermal growth factor and epidermal growth factor receptor immunoreactivity in the endothelial cells of the uterine artery and its branches during different stages of the estrous cycle in the pig. Andronowska, A., Postek, A., Doboszy??ska, T. Polish journal of veterinary sciences. (2006) [Pubmed]
  13. Effects of epidermal growth factor on acid secretion from guinea pig gastric mucosa: in vitro analysis. Finke, U., Rutten, M., Murphy, R.A., Silen, W. Gastroenterology (1985) [Pubmed]
  14. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. Chen, J.K., Wang, D.W., Falck, J.R., Capdevila, J., Harris, R.C. J. Biol. Chem. (1999) [Pubmed]
  15. [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone. Buck, P.A., Schomberg, D.W. Endocrinology (1988) [Pubmed]
  16. Characterization of the epidermal growth factor receptor in preimplantation pig conceptuses. Zhang, Y., Paria, B.C., Dey, S.K., Davis, D.L. Dev. Biol. (1992) [Pubmed]
  17. EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. Dong, J., Ramachandiran, S., Tikoo, K., Jia, Z., Lau, S.S., Monks, T.J. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  18. Transforming growth factor alpha inhibits secretion of gastric acid. Rhodes, J.A., Tam, J.P., Finke, U., Saunders, M., Bernanke, J., Silen, W., Murphy, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  19. Transforming growth factor-beta promotes epidermal growth factor-induced thyroid cell migration and follicle neoformation in collagen gel separable from cell proliferation. Nilsson, M., Dahlman, T., Westermark, B., Westermark, K. Exp. Cell Res. (1995) [Pubmed]
  20. Regulation of follistatin messenger ribonucleic acid in porcine granulosa cells by epidermal growth factor and the protein kinase-C pathway. Lindsell, C.E., Misra, V., Murphy, B.D. Endocrinology (1993) [Pubmed]
  21. Basic fibroblast and epidermal growth factors stimulate survival in adult porcine photoreceptor cell cultures. Traverso, V., Kinkl, N., Grimm, L., Sahel, J., Hicks, D. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  22. Epidermal growth factor-mediated inhibition of follicle-stimulating hormone-stimulated StAR gene expression in porcine granulosa cells is associated with reduced histone H3 acetylation. Rusovici, R., Hui, Y.Y., Lavoie, H.A. Biol. Reprod. (2005) [Pubmed]
  23. Mapping of the porcine AREG and EGF genes to SSC8. Kim, J.G., Vallet, J.L., Rohrer, G.A., Christenson, R.K. Anim. Genet. (2002) [Pubmed]
  24. Thyrocyte migration and histiotypic follicle regeneration are promoted by epidermal growth factor in primary culture of thyroid follicles in collagen gel. Westermark, K., Nilsson, M., Ebendal, T., Westermark, B. Endocrinology (1991) [Pubmed]
  25. Eye-derived growth factor isolated from bovine retina and used for epidermal wound healing in vivo. Fourtanier, A.Y., Courty, J., Muller, E., Courtois, Y., Prunieras, M., Barritault, D. J. Invest. Dermatol. (1986) [Pubmed]
  26. Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors. Ishiki, M., Sasaoka, T., Ishihara, H., Imamura, T., Usui, I., Takata, Y., Kobayashi, M. Endocrinology (1997) [Pubmed]
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