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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Unusual anaphylatoxin dynamics after head injury--case report.

The case reported exemplifies a clinical picture markedly at variance with the chronology of symptoms and laboratory findings generally held to be typical in patients with post-traumatic shock. During a protracted clinical course this young man with a skull fracture and epidural haematoma experienced profound hypotension and adult respiratory distress syndrome (ARDS) well in advance of marked fourfold rise of circulating peripheral C3a desArg anaphylatoxin levels. This raises a note of caution with regard to diagnostic and/or therapeutic decisions based on anaphylatoxin assessment of neurosurgical trauma patients at risk of ARDS.[1]


  1. Unusual anaphylatoxin dynamics after head injury--case report. Moskopp, D., Löcherbach-Zawadzky, A. Neurochirurgia. (1986) [Pubmed]
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