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MeSH Review


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Disease relevance of Hypotension


Psychiatry related information on Hypotension


High impact information on Hypotension

  • The rates of respiratory or circulatory complications (indicated by bag valve-mask ventilation or an attempt at intubation, hypotension, or cardiac dysrhythmia) after the study treatment was administered were 10.6 percent for the lorazepam group, 10.3 percent for the diazepam group, and 22.5 percent for the placebo group (P=0.08) [11].
  • Hypotension occurred in the clinic in 3.3 percent of men receiving alprostadil [12].
  • Thus, there exist both iNOS-dependent and iNOS-independent routes to LPS-induced hypotension and death [13].
  • Enhancement by an ACE inhibitor of first-dose hypotension caused by an alpha 1-blocker [14].
  • In comparison to the patients with normal renal function, those with renal failure were more often admitted with profound hypotension (46 vs. 4 percent; P less than 0.001), hyperpyrexia (69 vs. 15 percent; P less than 0.001), and markedly elevated serum creatine kinase levels (mean, 28,084 vs. 7931 U per liter; P less than 0.01) [15].

Chemical compound and disease context of Hypotension


Biological context of Hypotension


Anatomical context of Hypotension


Gene context of Hypotension

  • Thus, absence of NEP may predispose development of inflammation and hypotension [30].
  • Substance P (SP) and bradykinin (BK) mediate extravasation and cause hypotension [30].
  • However, the clinical utility of TNF has been limited by generalized toxicity and hypotension [31].
  • High concentrations of EPO occurred in patients experiencing significant hypotension despite routine transfusions for hematocrit < 42% [32].
  • Selective inhibition of VEGF signaling has been demonstrated in vivo in a growth factor-induced hypotension model in anesthetized rat: administration of ZD6474 (2.5 mg/kg, i.v.) reversed a hypotensive change induced by VEGF (by 63%) but did not significantly affect that induced by basic fibroblast growth factor [33].

Analytical, diagnostic and therapeutic context of Hypotension


  1. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. Kudenchuk, P.J., Cobb, L.A., Copass, M.K., Cummins, R.O., Doherty, A.M., Fahrenbruch, C.E., Hallstrom, A.P., Murray, W.A., Olsufka, M., Walsh, T. N. Engl. J. Med. (1999) [Pubmed]
  2. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Geller, D.S., Rodriguez-Soriano, J., Vallo Boado, A., Schifter, S., Bayer, M., Chang, S.S., Lifton, R.P. Nat. Genet. (1998) [Pubmed]
  3. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. Schwartz, L.B., Metcalfe, D.D., Miller, J.S., Earl, H., Sullivan, T. N. Engl. J. Med. (1987) [Pubmed]
  4. Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. Borer, J.S., Redwood, D.R., Levitt, B., Cagin, N., Bianchi, C., Vallin, H., Epstein, S.E. N. Engl. J. Med. (1975) [Pubmed]
  5. Comparison of captopril and enalapril in patients with severe chronic heart failure. Packer, M., Lee, W.H., Yushak, M., Medina, N. N. Engl. J. Med. (1986) [Pubmed]
  6. Extreme hypermagnesemia as a cause of refractory hypotension. Mordes, J.P., Swartz, R., Arky, R.A. Ann. Intern. Med. (1975) [Pubmed]
  7. The effect of 2 sympatholytic medications--propranolol and clonidine--on sleep bruxism: experimental randomized controlled studies. Huynh, N., Lavigne, G.J., Lanfranchi, P.A., Montplaisir, J.Y., de Champlain, J. Sleep. (2006) [Pubmed]
  8. Alterations in vasopressin regulation in Alzheimer's disease. Norbiato, G., Bevilacqua, M., Carella, F., Chebat, E., Raggi, U., Bertora, P., Grassi, M.P., Mangoni, A. J. Neurol. Neurosurg. Psychiatr. (1988) [Pubmed]
  9. Prospective comparative study with intracavernous sodium nitroprusside and prostaglandin E1 in patients with erectile dysfunction. Martínez-Piñeiro, L., Cortés, R., Cuervo, E., López-Tello, J., Cisneros, J., Martínez-Piñeiro, J.A. Eur. Urol. (1998) [Pubmed]
  10. Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats. El-Mas, M.M., Abdel-Rahman, A.A. J. Appl. Physiol. (2004) [Pubmed]
  11. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. Alldredge, B.K., Gelb, A.M., Isaacs, S.M., Corry, M.D., Allen, F., Ulrich, S., Gottwald, M.D., O'Neil, N., Neuhaus, J.M., Segal, M.R., Lowenstein, D.H. N. Engl. J. Med. (2001) [Pubmed]
  12. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. Padma-Nathan, H., Hellstrom, W.J., Kaiser, F.E., Labasky, R.F., Lue, T.F., Nolten, W.E., Norwood, P.C., Peterson, C.A., Shabsigh, R., Tam, P.Y. N. Engl. J. Med. (1997) [Pubmed]
  13. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. MacMicking, J.D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D.S., Trumbauer, M., Stevens, K., Xie, Q.W., Sokol, K., Hutchinson, N. Cell (1995) [Pubmed]
  14. Enhancement by an ACE inhibitor of first-dose hypotension caused by an alpha 1-blocker. Baba, T., Tomiyama, T., Takebe, K. N. Engl. J. Med. (1990) [Pubmed]
  15. Acute rhabdomyolysis associated with cocaine intoxication. Roth, D., Alarcón, F.J., Fernandez, J.A., Preston, R.A., Bourgoignie, J.J. N. Engl. J. Med. (1988) [Pubmed]
  16. Renin release, saralasin and the vasodilator-beta-blocker drug interaction in man. Pettinger, W.A., Mitchell, H.C. N. Engl. J. Med. (1975) [Pubmed]
  17. Hemodialysis using prostacyclin instead of heparin as the sole antithrombotic agent. Zusman, R.M., Rubin, R.H., Cato, A.E., Cocchetto, D.M., Crow, J.W., Tolkoff-Rubin, N. N. Engl. J. Med. (1981) [Pubmed]
  18. Nifedipine in unstable angina: a double-blind, randomized trial. Gerstenblith, G., Ouyang, P., Achuff, S.C., Bulkley, B.H., Becker, L.C., Mellits, E.D., Baughman, K.L., Weiss, J.L., Flaherty, J.T., Kallman, C.H., Llewellyn, M., Weisfeldt, M.L. N. Engl. J. Med. (1982) [Pubmed]
  19. Hypotension after quinidine plus verapamil. Possible additive competition at alpha-adrenergic receptors. Maisel, A.S., Motulsky, H.J., Insel, P.A. N. Engl. J. Med. (1985) [Pubmed]
  20. Effect of hypotension on liver blood flow and lidocaine disposition. Feely, J., Wade, D., McAllister, C.B., Wilkinson, G.R., Robertson, D. N. Engl. J. Med. (1982) [Pubmed]
  21. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Bátkai, S., Járai, Z., Wagner, J.A., Goparaju, S.K., Varga, K., Liu, J., Wang, L., Mirshahi, F., Khanolkar, A.D., Makriyannis, A., Urbaschek, R., Garcia, N., Sanyal, A.J., Kunos, G. Nat. Med. (2001) [Pubmed]
  22. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Oudit, G.Y., Sun, H., Trivieri, M.G., Koch, S.E., Dawood, F., Ackerley, C., Yazdanpanah, M., Wilson, G.J., Schwartz, A., Liu, P.P., Backx, P.H. Nat. Med. (2003) [Pubmed]
  23. Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis. Fuhrman, F.A., Fuhrman, G.J., Kim, Y.H., Pavelka, L.A., Mosher, H.S. Science (1980) [Pubmed]
  24. The renin-angiotensin system and thirst: a reevaluation. Stricker, E.M., Bradshaw, W.G., McDonald, R.H. Science (1976) [Pubmed]
  25. Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. Román, G.C. JAMA (1987) [Pubmed]
  26. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Wagner, J.A., Varga, K., Ellis, E.F., Rzigalinski, B.A., Martin, B.R., Kunos, G. Nature (1997) [Pubmed]
  27. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Talman, W.T., Perrone, M.H., Reis, D.J. Science (1980) [Pubmed]
  28. Interaction of cardiopulmonary and carotid baroreflex control of vascular resistance in humans. Victor, R.G., Mark, A.L. J. Clin. Invest. (1985) [Pubmed]
  29. Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine. Kilbourn, R.G., Gross, S.S., Lodato, R.F., Adams, J., Levi, R., Miller, L.L., Lachman, L.B., Griffith, O.W. J. Natl. Cancer Inst. (1992) [Pubmed]
  30. The control of microvascular permeability and blood pressure by neutral endopeptidase. Lu, B., Figini, M., Emanueli, C., Geppetti, P., Grady, E.F., Gerard, N.P., Ansell, J., Payan, D.G., Gerard, C., Bunnett, N. Nat. Med. (1997) [Pubmed]
  31. A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon. Welborn, M.B., Van Zee, K., Edwards, P.D., Pruitt, J.H., Kaibara, A., Vauthey, J.N., Rogy, M., Castleman, W.L., Lowry, S.F., Kenney, J.S., Stüber, D., Ettlin, U., Wipf, B., Loetscher, H., Copeland, E.M., Lesslauer, W., Moldawer, L.L. J. Exp. Med. (1996) [Pubmed]
  32. Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support. Rabinowitz, J., Petros, W.P., Stuart, A.R., Peters, W.P. Blood (1993) [Pubmed]
  33. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Wedge, S.R., Ogilvie, D.J., Dukes, M., Kendrew, J., Chester, R., Jackson, J.A., Boffey, S.J., Valentine, P.J., Curwen, J.O., Musgrove, H.L., Graham, G.A., Hughes, G.D., Thomas, A.P., Stokes, E.S., Curry, B., Richmond, G.H., Wadsworth, P.F., Bigley, A.L., Hennequin, L.F. Cancer Res. (2002) [Pubmed]
  34. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.F., Beslot, F., Böhme, G.A., Imperato, A., Pedrazzini, T., Roques, B.P., Vassart, G., Fratta, W., Parmentier, M. Science (1999) [Pubmed]
  35. Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group. Le Gall, J.R., Lemeshow, S., Leleu, G., Klar, J., Huillard, J., Rué, M., Teres, D., Artigas, A. JAMA (1995) [Pubmed]
  36. Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. Ochoa, J.B., Curti, B., Peitzman, A.B., Simmons, R.L., Billiar, T.R., Hoffman, R., Rault, R., Longo, D.L., Urba, W.J., Ochoa, A.C. J. Natl. Cancer Inst. (1992) [Pubmed]
  37. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Nava, E., Palmer, R.M., Moncada, S. Lancet (1991) [Pubmed]
  38. Comparative responses to dobutamine and nitroprusside in patients with chronic low output cardiac failure. Berkowitz, C., McKeever, L., Croke, R.P., Jacobs, W.R., Loeb, H.S., Gunnar, R.M. Circulation (1977) [Pubmed]
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