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MeSH Review

Respiratory Distress Syndrome, Adult

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Disease relevance of Respiratory Distress Syndrome, Adult


Psychiatry related information on Respiratory Distress Syndrome, Adult


High impact information on Respiratory Distress Syndrome, Adult


Chemical compound and disease context of Respiratory Distress Syndrome, Adult


Biological context of Respiratory Distress Syndrome, Adult

  • IMPLICATIONS: Strategies aimed at more uniform drug exposure or selective neutralization of chlorethylisocyanate, one of the two major hydrolysis products of BCNU, might reduce the incidence of acute lung injury following this regimen without major compromise of antitumor effect [16].
  • PURPOSE: The purpose of this study was to analyze clinical and pharmacokinetic data from our ongoing phase II trials and to determine whether there is an association between BCNU pharmacokinetics and acute lung injury following cyclophosphamide-cisplatin-BCNU therapy [16].
  • Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury [17].
  • These results indicate that apoptosis may play an important role in acute lung injury, and thus that inhibition of caspase activity may constitute a new therapeutic approach for treatment of this disease [18].
  • When equal doses of C3-activating activity of CVFn or CVFh were injected intravenously into rats, CVFh-treated rats failed to develop acute lung injury, whereas CVFn-treated animals showed pronounced increases in lung vascular permeability [19].

Anatomical context of Respiratory Distress Syndrome, Adult


Gene context of Respiratory Distress Syndrome, Adult


Analytical, diagnostic and therapeutic context of Respiratory Distress Syndrome, Adult


  1. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. Bertozzi, P., Astedt, B., Zenzius, L., Lynch, K., LeMaire, F., Zapol, W., Chapman, H.A. N. Engl. J. Med. (1990) [Pubmed]
  2. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Moghaddam, M.F., Grant, D.F., Cheek, J.M., Greene, J.F., Williamson, K.C., Hammock, B.D. Nat. Med. (1997) [Pubmed]
  3. Plasma tumor necrosis factor levels in patients with presumed sepsis. Results in those treated with antilipid A antibody vs placebo. de Groote, M.A., Martin, M.A., Densen, P., Pfaller, M.A., Wenzel, R.P. JAMA (1989) [Pubmed]
  4. Development and application of an enzyme-linked immunosorbent assay for the quantitation of alternative complement pathway activation in human serum. Mayes, J.T., Schreiber, R.D., Cooper, N.R. J. Clin. Invest. (1984) [Pubmed]
  5. Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor. Swope, M., Sun, H.W., Blake, P.R., Lolis, E. EMBO J. (1998) [Pubmed]
  6. Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia. Lois, M., Brown, L.A., Moss, I.M., Roman, J., Guidot, D.M. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  7. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. Bernard, G.R., Wheeler, A.P., Russell, J.A., Schein, R., Summer, W.R., Steinberg, K.P., Fulkerson, W.J., Wright, P.E., Christman, B.W., Dupont, W.D., Higgins, S.B., Swindell, B.B. N. Engl. J. Med. (1997) [Pubmed]
  8. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G.D., Mascarenhas, M.M., Garg, H.G., Quinn, D.A., Homer, R.J., Goldstein, D.R., Bucala, R., Lee, P.J., Medzhitov, R., Noble, P.W. Nat. Med. (2005) [Pubmed]
  9. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Göggel, R., Winoto-Morbach, S., Vielhaber, G., Imai, Y., Lindner, K., Brade, L., Brade, H., Ehlers, S., Slutsky, A.S., Schütze, S., Gulbins, E., Uhlig, S. Nat. Med. (2004) [Pubmed]
  10. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Donnelly, S.C., Haslett, C., Reid, P.T., Grant, I.S., Wallace, W.A., Metz, C.N., Bruce, L.J., Bucala, R. Nat. Med. (1997) [Pubmed]
  11. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. Meduri, G.U., Headley, A.S., Golden, E., Carson, S.J., Umberger, R.A., Kelso, T., Tolley, E.A. JAMA (1998) [Pubmed]
  12. Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. Taggart, C.C., Cryan, S.A., Weldon, S., Gibbons, A., Greene, C.M., Kelly, E., Low, T.B., O'neill, S.J., McElvaney, N.G. J. Exp. Med. (2005) [Pubmed]
  13. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Corne, J., Chupp, G., Lee, C.G., Homer, R.J., Zhu, Z., Chen, Q., Ma, B., Du, Y., Roux, F., McArdle, J., Waxman, A.B., Elias, J.A. J. Clin. Invest. (2000) [Pubmed]
  14. Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. Holguin, F., Moss, I., Brown, L.A., Guidot, D.M. J. Clin. Invest. (1998) [Pubmed]
  15. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. Haddad, I.Y., Pataki, G., Hu, P., Galliani, C., Beckman, J.S., Matalon, S. J. Clin. Invest. (1994) [Pubmed]
  16. Acute lung injury following treatment with high-dose cyclophosphamide, cisplatin, and carmustine: pharmacodynamic evaluation of carmustine. Jones, R.B., Matthes, S., Shpall, E.J., Fisher, J.H., Stemmer, S.M., Dufton, C., Stephens, J.K., Bearman, S.I. J. Natl. Cancer Inst. (1993) [Pubmed]
  17. Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. He, C.H., Waxman, A.B., Lee, C.G., Link, H., Rabach, M.E., Ma, B., Chen, Q., Zhu, Z., Zhong, M., Nakayama, K., Nakayama, K.I., Homer, R., Elias, J.A. J. Clin. Invest. (2005) [Pubmed]
  18. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Kawasaki, M., Kuwano, K., Hagimoto, N., Matsuba, T., Kunitake, R., Tanaka, T., Maeyama, T., Hara, N. Am. J. Pathol. (2000) [Pubmed]
  19. Activation of C5 by cobra venom factor is required in neutrophil-mediated lung injury in the rat. Till, G.O., Morganroth, M.L., Kunkel, R., Ward, P.A. Am. J. Pathol. (1987) [Pubmed]
  20. Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. Folz, R.J., Abushamaa, A.M., Suliman, H.B. J. Clin. Invest. (1999) [Pubmed]
  21. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Matute-Bello, G., Winn, R.K., Jonas, M., Chi, E.Y., Martin, T.R., Liles, W.C. Am. J. Pathol. (2001) [Pubmed]
  22. Activator protein-1 activation in acute lung injury. Guo, R.F., Lentsch, A.B., Sarma, J.V., Sun, L., Riedemann, N.C., McClintock, S.D., McGuire, S.R., Van Rooijen, N., Ward, P.A. Am. J. Pathol. (2002) [Pubmed]
  23. Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. Matute-Bello, G., Lee, J.S., Liles, W.C., Frevert, C.W., Mongovin, S., Wong, V., Ballman, K., Sutlief, S., Martin, T.R. J. Immunol. (2005) [Pubmed]
  24. Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. Horowitz, J.C., Lee, D.Y., Waghray, M., Keshamouni, V.G., Thomas, P.E., Zhang, H., Cui, Z., Thannickal, V.J. J. Biol. Chem. (2004) [Pubmed]
  25. The role of endothelial PI3Kgamma activity in neutrophil trafficking. Puri, K.D., Doggett, T.A., Huang, C.Y., Douangpanya, J., Hayflick, J.S., Turner, M., Penninger, J., Diacovo, T.G. Blood (2005) [Pubmed]
  26. Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. Rowe, S.J., Allen, L., Ridger, V.C., Hellewell, P.G., Whyte, M.K. J. Immunol. (2002) [Pubmed]
  27. Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats. Bless, N.M., Huber-Lang, M., Guo, R.F., Warner, R.L., Schmal, H., Czermak, B.J., Shanley, T.P., Crouch, L.D., Lentsch, A.B., Sarma, V., Mulligan, M.S., Friedl, H.P., Ward, P.A. J. Immunol. (2000) [Pubmed]
  28. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. Owen, C.A., Hu, Z., Lopez-Otin, C., Shapiro, S.D. J. Immunol. (2004) [Pubmed]
  29. Experimental acute alveolar injury in the dog. Morphologic--mechanical correlations. Ryan, S.F., Bell, A.L., Barrett, C.R. Am. J. Pathol. (1976) [Pubmed]
  30. Pathogenesis and treatment of the adult respiratory distress syndrome. Fulkerson, W.J., MacIntyre, N., Stamler, J., Crapo, J.D. Arch. Intern. Med. (1996) [Pubmed]
  31. Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? Vadász, I., Morty, R.E., Kohstall, M.G., Olschewski, A., Grimminger, F., Seeger, W., Ghofrani, H.A. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  32. Lavage administration of dilute surfactants after acute lung injury in neonatal piglets. Balaraman, V., Meister, J., Ku, T.L., Sood, S.L., Tam, E., Killeen, J., Uyehara, C.F., Egan, E., Easa, D. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
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