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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Retro-Gasserian glycerol injection in the treatment of chronic cluster headache.

Seven therapy-resistant patients with cluster headache (six of whom were chronic) were treated by percutaneous retro-Gasserian glycerol injections under general anesthesia. In four of the patients immediate and complete relief of attacks was obtained. There was a close correlation between pain relief and the degree of ophthalmic sensory loss. Quantitative estimation of thresholds for thermal perception and pain showed a good correlation to clinically evaluated sensory loss. As the analgesia waned, headaches returned, and the glycerol injections had to be repeated. Two patients were still considerably improved after 5 1/2 and nearly 3 years, respectively. In the other patients the results were less satisfactory at long-term follow-up study. Pure glycerol is highly hypertonic, and the damage of the trigeminal nerve root may be due to this property.[1]

References

  1. Retro-Gasserian glycerol injection in the treatment of chronic cluster headache. Ekbom, K., Lindgren, L., Nilsson, B.Y., Hardebo, J.E., Waldenlind, E. Cephalalgia : an international journal of headache. (1987) [Pubmed]
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