Peripheral blood lymphocyte subsets in nasopharyngeal carcinoma.
Peripheral blood lymphocyte subsets were studied in 29 untreated Chinese nasopharyngeal carcinoma ( NPC) patients and 20 normal controls of similar age range and sex ratio with indirect immunofluorescence using monoclonal antibodies. The percentage T lymphocyte ( T11) count, percentage and absolute T helper (T4) lymphocyte counts and the T helper/T suppressor-cytotoxic cell ratio (T4/T8) were significantly lower, while the percentage and absolute T8 counts were significantly higher in NPC patients. Concerning B lymphocytes, B1 cell count was normal while B4 cell count (B lymphocytes including early B lymphocytes) was significantly lower in NPC patients. These various lymphocyte subset changes were not related to the clinical stage or to Epstein-Barr viral IgA viral capsid antibodies and IgA early antibodies. The pathogenetic and prognostic significance of peripheral blood lymphocyte changes in NPC requires further investigation.[1]References
- Peripheral blood lymphocyte subsets in nasopharyngeal carcinoma. Ng, C.S., Chick, W., Tsao, S.Y., O, S.K., Sung, J.Y., Lee, J.C., Shiu, W., Cheng, P.N., Martin, W.M. Oncology (1987) [Pubmed]
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