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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

High-level, heat-regulated synthesis of proteins in eukaryotic cells.

Plasmids have been constructed in which promoters of 70-kDa heat-shock protein genes (hsp70) of human and Drosophila origin were linked to three different eukaryotic genes encoding human growth hormone ( hGH), chicken lysozyme (cL) and a human influenza haemagglutinin (HA). Following transfection into widely divergent eukaryotic cells, the hybrid genes direct the transient, heat-regulated synthesis of the three proteins. hGH and cL are secreted into the medium. A human hsp70- hGH construct was used to establish stable mouse fibroblast lines that are capable of producing and secreting hGH at high levels following heat induction: hGH is secreted at a 500-1200-fold higher rate by heat-treated than by untreated cells.[1]


  1. High-level, heat-regulated synthesis of proteins in eukaryotic cells. Dreano, M., Brochot, J., Myers, A., Cheng-Meyer, C., Rungger, D., Voellmy, R., Bromley, P. Gene (1986) [Pubmed]
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