A study of immune responses to Tamm-Horsfall glycoprotein in the sera of patients with renal tubular acidosis.
Antibody to Tamm-Horsfall glycoprotein in the sera of patients with distal renal tubular acidosis (dRTA) was measured by radioimmunoassay, as well as in samples of normal human serum. Normal human serum contains small amounts of IgG capable of interacting with Tamm-Horsfall glycoprotein. Appropriate assays were carried out on antiserum raised in rabbits against human Tamm-Horsfall glycoprotein serially diluted with normal human serum. Corrections were applied for the presence of interfering substances in serum. The amounts of antibody found in samples of normal and patient sera were not significantly different, although some of the patients were diagnosed as having immune as opposed to familial dRTA. Studies of cell-mediated immunity to Tamm-Horsfall glycoprotein was found not to differentiate between the normal and patient samples. dRTA does not appear to be associated with immune responses to Tamm-Horsfall glycoprotein.[1]References
- A study of immune responses to Tamm-Horsfall glycoprotein in the sera of patients with renal tubular acidosis. Duffy, F.A., Marshall, R.D., Wrong, O. Clin. Nephrol. (1987) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
