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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat.

Injection of 2 micrograms (+/-)-baclofen into the ventromedial hypothalamus (VMH) of urethane-anaesthetized rats resulted in an increase in gastric tone and amplitude of contractions. This effect was curtailed by administration of atropine methyl nitrate (20 mg/kg i.p.) or bilateral cervical vagotomy. These results provide evidence for a hypothalamic modulation of gastric motility by the vagus. Baclofen, possibly acting on receptors insensitive to gamma-aminobutyric acid (GABA), may be mimicking a vagal activation system, located within the ventro-medial hypothalamus.[1]

References

  1. Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat. Wood, K.L., Addae, J.I., Andrews, P.L., Stone, T.W. Neuropharmacology (1987) [Pubmed]
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