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Disease relevance of Vagotomy


Psychiatry related information on Vagotomy

  • The vagotomized rats retained the capacity to rapidly increase eating in response to food deprivation or insulin injection challenges, indicating that the effect of vagotomy on NE-induced eating was not due to some non-specific impairment [6].
  • The failure of rats given hepatic vagotomy to increase food intake and food preference when drinking saccharin suggests that a hepatic mechanism is involved [7].
  • Ceruletide at a dose of 100 micrograms/kg reduced the rates of spontaneous locomotor activity and rearing, and also inhibited methylphenidate- and methamphetamine-induced hyperactivity in both sham-operated and vagotomized mice to same extent, whereas bilateral subdiaphragmatic vagotomy attenuated these behavioral parameters [8].

High impact information on Vagotomy

  • The effect of CCK on OT secretion was blunted after gastric vagotomy, as was the inhibition of food intake induced by CCK [9].
  • Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat [10].
  • The response was blocked by atropine and by vagotomy [11].
  • Surgical or chemical vagotomy rendered animals sensitive to TNF release and shock, despite treatment with CNI-1493, indicating that an intact cholinergic antiinflammatory pathway is required for antiinflammatory efficacy in vivo [12].
  • To determine whether these changes could be responsible for the increased sensitivity of the beta cell to glucose, insulin release in response to glucose was measured in HG and control rats, either under subdiaphragmatic vagotomy or after administration of the alpha 2A-adrenergic agonist oxymetazoline [13].

Chemical compound and disease context of Vagotomy


Biological context of Vagotomy

  • The effect of metoclopramide, a stimulant of gastric motility, on gastric emptying was tested in 6 patients with chronic gastric retention after vagotomy and gastric resection, unexplained by mechanical obstruction or stomal ulceration [19].
  • Bilateral cervical vagotomy and stimulation of the distal cut end initiates peristaltic contraction indicating that the propagative nature of peristalsis in the smooth musurrent, does not alter mucosal cyclic AMP [20].
  • Unilateral right vagotomy reduced resting levels of plasma ANP but not the response to blood volume expansion; resting concentrations of plasma ANP and responses to expansion were normal in bilaterally vagotomized rats [21].
  • The decreases in renal SNA and heart rate were reversed by cervical vagotomy but not by atropine, which indicates vagal afferent mediation [22].
  • Bilateral cervical vagotomy abolished the decreases of blood pressure, heart rate, and renal sympathetic nerve activity after intrapericardial phenylbiguanide but did not influence the responses to intrapericardial bradykinin [23].

Anatomical context of Vagotomy


Associations of Vagotomy with chemical compounds

  • All of these actions of histamine were abolished by vagotomy [29].
  • Neither bilateral cervical vagotomy nor beta adrenergic blockade with propranolol significantly diminished the increase in vascular capacity associated with infusions of PGI2 [30].
  • Gastrin-17 infusion did not inhibit gastric HCO3- secretion after vagotomy [31].
  • The inhibitory effects of cerebroventricular CGRP were abolished by ganglionic blockade with chlorisondamine, significantly attenuated by noradrenergic blockade with bretylium, and enhanced by vagotomy [32].
  • This study investigated in vivo (1) the effect of rectal distention (RD) on proximal colonic net water flux, (2) the role of tachykinins, and muscarinic and nicotinic connections, and (3) the influence of capsaicin-sensitive nerves and vagotomy in this effect [33].

Gene context of Vagotomy

  • Secretin-induced choleresis of BDL rats was virtually eliminated by vagotomy in association with decreased cholangiocyte cAMP levels [34].
  • RESULTS: : Ghrelin exhibited gastroprokinetic activity with structural resemblance to motilin and potent orexigenic activity through action on the hypothalamic neuropeptide Y (NPY) and Y(1) receptor, which was lost after vagotomy [35].
  • Finally, subdiaphragmatic vagotomy was found to attenuate the reduction in food-motivated behavior induced by both IL-1 beta and lipopolysaccharide in mice [36].
  • Cervical vagotomy (extirpation of the nodose ganglion) reduced the number of NKA- and GAL-containing fibers in the thyroid by approximately 50% [37].
  • Moreover, the upregulation of TNF-alpha immunoreactivity and significantly increased number of TNF-alpha-immunopositive cells were observed in the injured DMV at 7 and 14 days, and the increase in SDF-1-immunopositive cells at 14 days, after right vagotomy [38].

Analytical, diagnostic and therapeutic context of Vagotomy


  1. Influence of parietal cell vagotomy and selective gastric vagotomy on gastric emptying rate and serum gastrin concentration. Brandsborg, O., Brandsborg, M., Lovgreen, N.A., Mikkelsen, K., Moller, B., Rokkjaer, M., Amdrup, E. Gastroenterology (1977) [Pubmed]
  2. Effect of vagotomy in Zollinger-Ellison syndrome. Richardson, C.T., Feldman, M., McClelland, R.N., Dickerman, R.M., Kumpuris, D., Fordtran, J.S. Gastroenterology (1979) [Pubmed]
  3. Vagotomy-induced enhancement of mechanical hyperalgesia in the rat is sympathoadrenal-mediated. Khasar, S.G., Miao, F.J., Jänig, W., Levine, J.D. J. Neurosci. (1998) [Pubmed]
  4. Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia. Fujita, S., Donovan, C.M. Diabetes (2005) [Pubmed]
  5. Surgical treatment of recurrent peptic ulcer disease. Heppell, J., Bess, M.A., McIlrath, D.C., Dozois, R.R. Ann. Surg. (1983) [Pubmed]
  6. Evidence for vagal involvement in the eating elicited by adrenergic stimulation of the paraventricular nucleus. Sawchenko, P.E., Gold, R.M., Leibowitz, S.F. Brain Res. (1981) [Pubmed]
  7. Drinking saccharin increases food intake and preference--IV. Cephalic phase and metabolic factors. Tordoff, M.G., Friedman, M.I. Appetite. (1989) [Pubmed]
  8. Bilateral subdiaphragmatic vagotomy does not prevent the behavioral effects of systematically administered ceruletide in mice. Moroji, T., Hagino, Y. Neuropeptides (1987) [Pubmed]
  9. Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety. Verbalis, J.G., McCann, M.J., McHale, C.M., Stricker, E.M. Science (1986) [Pubmed]
  10. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Smith, G.P., Jerome, C., Cushin, B.J., Eterno, R., Simansky, K.J. Science (1981) [Pubmed]
  11. Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats. Tepperman, B.L., Evered, M.D. Science (1980) [Pubmed]
  12. Pharmacological stimulation of the cholinergic antiinflammatory pathway. Bernik, T.R., Friedman, S.G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C.J., Ivanova, S.M., Tracey, K.J. J. Exp. Med. (2002) [Pubmed]
  13. Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta cell in rats. N'Guyen, J.M., Magnan, C., Laury, M.C., Thibault, C., Leveteau, J., Gilbert, M., Pénicaud, L., Ktorza, A. J. Clin. Invest. (1994) [Pubmed]
  14. Effect of vagotomy on the gastric secretory response to intraduodenal osmotic agents in man. Ward, A.S. Gut (1976) [Pubmed]
  15. Sample taking problems in measuring actual histamine levels of human gastroduodenal mucosa: specific and general relevance in clinical trials on peptic ulcer pathogenesis and selective proximal vagotomy. Thon, K.P., Lorenz, W., Ohmann, C., Weber, D., Rohde, H., Röher, H.D. Gut (1985) [Pubmed]
  16. Proline is not useful as a chemical probe to measure nitrosation in the gastrointestinal tract of patients with gastric disorders characterised by anacidic conditions. Adam, B., Schlag, P., Friedl, P., Preussmann, R., Eisenbrand, G. Gut (1989) [Pubmed]
  17. Elevated plasma noradrenaline concentrations in duodenal ulcer patients are not normalized by vagotomy. Christensen, N.J., Brandsborg, O., Løvgreen, N.A., Brandsborg, M. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  18. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. van Westerloo, D.J., Giebelen, I.A., Florquin, S., Daalhuisen, J., Bruno, M.J., de Vos, A.F., Tracey, K.J., van der Poll, T. J. Infect. Dis. (2005) [Pubmed]
  19. Effect of metoclopramide in chronic gastric retention after gastric surgery. Metzger, W.H., Cano, R., Sturdevant, R.A. Gastroenterology (1976) [Pubmed]
  20. Neural organization of esophageal peristalsis: role of vagus nerve. Mukhopadhyay, A.K., Weisbrodt, N.W. Gastroenterology (1975) [Pubmed]
  21. Carotid-aortic and renal baroreceptors mediate the atrial natriuretic peptide release induced by blood volume expansion. Antunes-Rodrigues, J., Machado, B.H., Andrade, H.A., Mauad, H., Ramalho, M.J., Reis, L.C., Silva-Netto, C.R., Favaretto, A.L., Gutkowska, J., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats. Victor, R.G., Thorén, P., Morgan, D.A., Mark, A.L. Circ. Res. (1989) [Pubmed]
  23. Epicardial bradykinin B2 receptors elicit a sympathoexcitatory reflex in rats. Veelken, R., Glabasnia, A., Stetter, A., Hilgers, K.F., Mann, J.F., Schmieder, R.E. Hypertension (1996) [Pubmed]
  24. Central nervous system action of thyrotropin-releasing hormone to increase gastric mucosal blood flow in the rat. Thiefin, G., Taché, Y., Leung, F.W., Guth, P.H. Gastroenterology (1989) [Pubmed]
  25. Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine. Sternini, C., Wong, H., Pham, T., De Giorgio, R., Miller, L.J., Kuntz, S.M., Reeve, J.R., Walsh, J.H., Raybould, H.E. Gastroenterology (1999) [Pubmed]
  26. Gastric inflammation triggers hypersensitivity to acid in awake rats. Lamb, K., Kang, Y.M., Gebhart, G.F., Bielefeldt, K. Gastroenterology (2003) [Pubmed]
  27. Bilary lipids and bile acid pool size after vagotomy in man. Evidence against a predisposition to gallstones. Stempel, J.M., Duane, W.C. Gastroenterology (1978) [Pubmed]
  28. Central nervous system mechanisms involved in inhibition of renal sympathetic nerve activity induced by arginine vasopressin. Suzuki, S., Takeshita, A., Imaizumi, T., Hirooka, Y., Yoshida, M., Ando, S., Nakamura, M. Circ. Res. (1989) [Pubmed]
  29. Reflex effects of aerosolized histamine on phrenic nerve activity. Pack, A.I., Hertz, B.C., Ledlie, J.F., Fishman, A.P. J. Clin. Invest. (1982) [Pubmed]
  30. Effect of prostacyclin on vascular capacity in the dog. Fulghum, T.G., DiMarco, J.P., Supple, E.W., Nash, I., Gendlerman, J., Eton, D.F., Newell, J.B., Zusman, R.M., Powell, W.J. J. Clin. Invest. (1985) [Pubmed]
  31. Effect of proximal gastric vagotomy on calculated gastric HCO3- and nonparietal volume secretion in man. Studies during basal conditions and gastrin-17 infusion. Feldman, M., Blair, A.J., Richardson, C.T. J. Clin. Invest. (1987) [Pubmed]
  32. Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin. Lenz, H.J., Brown, M.R. J. Clin. Invest. (1990) [Pubmed]
  33. Rectal distention-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory, and vagus nerves. Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L. Gastroenterology (1997) [Pubmed]
  34. Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. LeSagE, G., Alvaro, D., Benedetti, A., Glaser, S., Marucci, L., Baiocchi, L., Eisel, W., Caligiuri, A., Phinizy, J.L., Rodgers, R., Francis, H., Alpini, G. Gastroenterology (1999) [Pubmed]
  35. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M.A., Kasuga, M. Gastroenterology (2001) [Pubmed]
  36. Mechanisms of sickness-induced decreases in food-motivated behavior. Kent, S., Bret-Dibat, J.L., Kelley, K.W., Dantzer, R. Neuroscience and biobehavioral reviews. (1996) [Pubmed]
  37. Neurokinin A and galanin in the thyroid gland: neuronal localization. Grunditz, T., Hakanson, R., Sundler, F., Uddman, R. Endocrinology (1987) [Pubmed]
  38. Expressions of cytokines and chemokines in the dorsal motor nucleus of the vagus nerve after right vagotomy. Ji, J.F., Dheen, S.T., Kumar, S.D., He, B.P., Tay, S.S. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  39. Pancreatic secretory response to intravenous caerulein and intraduodenal tryptophan studies: before and after stepwise removal of the extrinsic nerves of the pancreas in dogs. Singer, M.V., Niebel, W., Jansen, J.B., Hoffmeister, D., Gotthold, S., Goebell, H., Lamers, C.B. Gastroenterology (1989) [Pubmed]
  40. Effect of parietal cell vagotomy on acid secretory responsiveness to circulating gastrin in humans. Relationship to postprandial serum gastrin concentration. Blair, A.J., Richardson, C.T., Walsh, J.H., Chew, P., Feldman, M. Gastroenterology (1986) [Pubmed]
  41. Indomethacin produces gastric antral ulcers in the refed rat. Satoh, H., Inada, I., Hirata, T., Maki, Y. Gastroenterology (1981) [Pubmed]
  42. Effects of diazepam and Ro 15-1788 on duodenal bicarbonate secretion in the rat. Säfsten, B., Jedstedt, G., Flemström, G. Gastroenterology (1991) [Pubmed]
  43. Abnormal oral glucose tolerance and glucose malabsorption after vagotomy and pyloroplasty. A tracer method for measuring glucose absorption rates. Radziuk, J., Bondy, D.C. Gastroenterology (1982) [Pubmed]
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