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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Regression of melanoma nodules in a patient treated with ranitidine.

Human malignant melanoma may regress spontaneously or with immunotherapy, such as Calmette-Guerin bacillus, interferon alfa, interleukin-2, and interleukin-2 plus lymphokine-activated killer cells. Histamine type 2 receptor antagonists can modulate immune function by inhibiting suppressor T-cell induction and activity, and melanoma regressions have been reported after the use of cimetidine with coumarin or interferon alfa. This article describes the complete regression of melanoma nodules in a patient treated with ranitidine hydrochloride, another histamine type 2-receptor antagonist. Ranitidine and cimetidine should be considered to be possibly active immunotherapeutic agents in the design and evaluation of clinical trials.[1]


  1. Regression of melanoma nodules in a patient treated with ranitidine. Smith, T., Clark, J.W., Popp, M.B. Arch. Intern. Med. (1987) [Pubmed]
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