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Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug.

1. The pharmacological properties of a water extract of the Zizyphus seed (HO2) and that of the Zizyphus seed containing drug ( HO1) were studied. 2. After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, the hypnotic effects induced by hexobarbital-Na (38 mg/kg, i.p.) and diazepam-induced sleep in mice were potentiated. 3. After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, gastric juice secretion and ulcers induced by water immersion stress, histamine and reserpine in rats were inhibited.[1]

References

  1. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Morishita, S., Mishima, Y., Hirai, Y., Saito, T., Shoji, M. Gen. Pharmacol. (1987) [Pubmed]
 
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