Disease relevance of Ziziphus

• The modulating effect of dietary Zizyphus mistol seed oil, rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid, on two murine mammary gland adenocarcinomas having low (M2) and high (MM3) metastatic abilities was investigated [1].

High impact information on Ziziphus

• Sera from two Indian jujube skin test-positive latex-allergic subjects were used for allergen-specific IgE, immunoblotting, immunoblot inhibition and enzyme-linked immunosorbent assay (ELISA) inhibition studies [2].
• Allergenic components of Indian jujube (Zizyphus mauritiana) show IgE cross-reactivity with latex allergen [2].
• Preincubation of atopic sera with Indian jujube or latex extract demonstrated absent and/or marked inhibition of IgE binding [2].
• Significant genetic differentiation was found between the subpopulations on both sides of the Great Wall. A wind-pollinated woody species, Ulmus pumila, showed less genetic differentiation than four insect-pollinated species: Prunus armeniaca, Ziziphus jujuba, Vitex negundo, and Heteropappus hispidus [3].
• Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay [4].

Biological context of Ziziphus

• The only 90% methanol extracts that were mutagenic in strain TA98 were from the leaves of C. roseus and Ziziphus mucronata in the presence of metabolic activation [5].
• Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA [6].

Anatomical context of Ziziphus

• Following the elucidation of jujubosides A1 and C and acetyljujuboside B, novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu [7].

Associations of Ziziphus with chemical compounds

• CONCLUSIONS: Our results add to findings regarding the 'latex-fruit syndrome' described in the literature, and further study of the cross-reacting allergens identified in Indian jujube may help to elucidate the mechanisms underlying this syndrome [2].
• From the butanol extract of the leaves of Zizyphus spina-christi (L.) Willd [8].
• Terephthalic acid and its methyl esters from Zizyphus sativa [9].
• The present study aims to investigate the effect of the butanol extract of Zizyphus spina-christi leaves as well as christinin-A, its principle saponin glycoside, in normal and streptozotocin-diabetic rats [10].
• Four new dammarane saponins from Zizyphus lotus [11].

Gene context of Ziziphus

• 1. The pharmacological properties of a water extract of the Zizyphus seed (HO2) and that of the Zizyphus seed containing drug (HO1) were studied [12].
• The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated [13].

Analytical, diagnostic and therapeutic context of Ziziphus

• Immunoblotting revealed that IgE from both subjects bound to a 42-kD latex protein and a 42-kD Indian jujube protein [2].
• RESULTS: Both patients had positive skin test responses and specific IgE assays to Indian jujube and latex extracts [2].
• Molecular cloning of Indian jujube (Zizyphus mauritiana) allergen Ziz m 1 with sequence similarity to plant class III chitinases [14].

References