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MeSH Review


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Disease relevance of Ziziphus


High impact information on Ziziphus


Biological context of Ziziphus


Anatomical context of Ziziphus

  • Following the elucidation of jujubosides A1 and C and acetyljujuboside B, novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu [7].

Associations of Ziziphus with chemical compounds

  • CONCLUSIONS: Our results add to findings regarding the 'latex-fruit syndrome' described in the literature, and further study of the cross-reacting allergens identified in Indian jujube may help to elucidate the mechanisms underlying this syndrome [2].
  • From the butanol extract of the leaves of Zizyphus spina-christi (L.) Willd [8].
  • Terephthalic acid and its methyl esters from Zizyphus sativa [9].
  • The present study aims to investigate the effect of the butanol extract of Zizyphus spina-christi leaves as well as christinin-A, its principle saponin glycoside, in normal and streptozotocin-diabetic rats [10].
  • Four new dammarane saponins from Zizyphus lotus [11].

Gene context of Ziziphus

  • 1. The pharmacological properties of a water extract of the Zizyphus seed (HO2) and that of the Zizyphus seed containing drug (HO1) were studied [12].
  • The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated [13].

Analytical, diagnostic and therapeutic context of Ziziphus


  1. Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. Muñoz, S.F., Silva, R.A., Lamarque, A., Guzmán, C.A., Eynard, A.R. Prostaglandins Leukot. Essent. Fatty Acids (1995) [Pubmed]
  2. Allergenic components of Indian jujube (Zizyphus mauritiana) show IgE cross-reactivity with latex allergen. Lee, M.F., Chen, Y.H., Lan, J.L., Tseng, C.Y., Wu, C.H. Int. Arch. Allergy Immunol. (2004) [Pubmed]
  3. The Great Wall of China: a physical barrier to gene flow? Su, H., Qu, L.J., He, K., Zhang, Z., Wang, J., Chen, Z., Gu, H. Heredity (2003) [Pubmed]
  4. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Su, B.N., Cuendet, M., Farnsworth, N.R., Fong, H.H., Pezzuto, J.M., Kinghorn, A.D. Planta Med. (2002) [Pubmed]
  5. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Elgorashi, E.E., Taylor, J.L., Maes, A., van Staden, J., De Kimpe, N., Verschaeve, L. Toxicol. Lett. (2003) [Pubmed]
  6. Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Hatano, T., Kusuda, M., Inada, K., Ogawa, T.O., Shiota, S., Tsuchiya, T., Yoshida, T. Phytochemistry (2005) [Pubmed]
  7. Bioactive saponins and glycosides. XIV. Structure elucidation and immunological adjuvant activity of novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, from the seeds of Zizyphus jujuba var. spinosa (Zizyphi Spinosi Semen). Matsuda, H., Murakami, T., Ikebata, A., Yamahara, J., Yoshikawa, M. Chem. Pharm. Bull. (1999) [Pubmed]
  8. Novel Saponins from Zizyphus spina-christi growing in Egypt. el-Din Hussein Mahran, G., Glombitza, K.W., Mirhom, Y.W., Hartmann, R., Michel, C.G. Planta Med. (1996) [Pubmed]
  9. Terephthalic acid and its methyl esters from Zizyphus sativa. Thakur, R.S., Jain, M.P., Hruban, L., Santavý, F. Planta Med. (1975) [Pubmed]
  10. Hypoglycemic and antihyperglycemic effects of Zizyphus spina-christi in rats. Glombitza, K.W., Mahran, G.H., Mirhom, Y.W., Michel, K.G., Motawi, T.K. Planta Med. (1994) [Pubmed]
  11. Four new dammarane saponins from Zizyphus lotus. Maciuk, A., Lavaud, C., Thépenier, P., Jacquier, M.J., Ghédira, K., Zèches-Hanrot, M. J. Nat. Prod. (2004) [Pubmed]
  12. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Morishita, S., Mishima, Y., Hirai, Y., Saito, T., Shoji, M. Gen. Pharmacol. (1987) [Pubmed]
  13. Inhibition of calmodulin-dependent protein kinase II by cyclic and linear peptide alkaloids from Zizyphus species. Han, Y.N., Hwang, K.H., Han, B.H. Arch. Pharm. Res. (2005) [Pubmed]
  14. Molecular cloning of Indian jujube (Zizyphus mauritiana) allergen Ziz m 1 with sequence similarity to plant class III chitinases. Lee, M.F., Hwang, G.Y., Chen, Y.H., Lin, H.C., Wu, C.H. Mol. Immunol. (2006) [Pubmed]
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