Gene Review:
Hmox2 - heme oxygenase (decycling) 2
Rattus norvegicus
Synonyms:
HO-2, Heme oxygenase 2
- Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Ewing, J.F., Maines, M.D. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver. Bauer, I., Wanner, G.A., Rensing, H., Alte, C., Miescher, E.A., Wolf, B., Pannen, B.H., Clemens, M.G., Bauer, M. Hepatology (1998)
- Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes. Rublevskaya, I., Maines, M.D. J. Biol. Chem. (1994)
- Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats. Govindaraju, V., Teoh, H., Hamid, Q., Cernacek, P., Ward, M.E. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate. Ewing, J.F., Raju, V.S., Maines, M.D. J. Pharmacol. Exp. Ther. (1994)
- The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Maines, M.D., Panahian, N. Adv. Exp. Med. Biol. (2001)
- Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock. Artinian, L.R., Ding, J.M., Gillette, M.U. Exp. Neurol. (2001)
- Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. Kaide, J.I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W.H., Balazy, M., Abraham, N.G., Nasjletti, A. J. Clin. Invest. (2001)
- Carbon monoxide stimulates the apical 70-pS K+ channel of the rat thick ascending limb. Liu, H., Mount, D.B., Nasjletti, A., Wang, W. J. Clin. Invest. (1999)
- Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Ishizaka, N., de León, H., Laursen, J.B., Fukui, T., Wilcox, J.N., De Keulenaer, G., Griendling, K.K., Alexander, R.W. Circulation (1997)
- Carbon monoxide: a role in carotid body chemoreception. Prabhakar, N.R., Dinerman, J.L., Agani, F.H., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. McCoubrey, W.K., Huang, T.J., Maines, M.D. J. Biol. Chem. (1997)
- Nitric oxide synthase-I containing cortical interneurons co-express antioxidative enzymes and anti-apoptotic Bcl-2 following focal ischemia: evidence for direct and indirect mechanisms towards their resistance to neuropathology. Bidmon, H.J., Emde, B., Kowalski, T., Schmitt, M., Mayer, B., Kato, K., Asayama, K., Witte, O.W., Zilles, K. J. Chem. Neuroanat. (2001)
- Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord. Sharma, H.S., Westman, J. Acta Neurochir. Suppl. (2003)
- Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. Sharma, H.S., Drieu, K., Westman, J. Acta Neurochir. Suppl. (2003)
- Evidence suggesting that the two forms of heme oxygenase are products of different genes. Cruse, I., Maines, M.D. J. Biol. Chem. (1988)
- Multiple transcripts encoding heme oxygenase-2 in rat testis: developmental and cell-specific regulation of transcripts and protein. McCoubrey, W.K., Eke, B., Maines, M.D. Biol. Reprod. (1995)
- Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene. Hayashi, S., Omata, Y., Sakamoto, H., Higashimoto, Y., Hara, T., Sagara, Y., Noguchi, M. Gene (2004)
- Localization of heme oxygenase in rat retina: effect of light adaptation. Nishimura, R.N., Dwyer, B.E., Lu, S.Y. Neurosci. Lett. (1996)
- Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis. Bidmon, H.J., Emde, B., Oermann, E., Kubitz, R., Witte, O.W., Zilles, K. Exp. Neurol. (2001)
- Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Liu, N., Wang, X., McCoubrey, W.K., Maines, M.D. Gene (2000)
- Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in the hippocampus of stressed rats. Chen, Z., Xu, H., Haimano, S., Li, X., Li, X.M. Neurosci. Lett. (2005)
- Expression and actions of heme oxygenase in the renal medulla of rats. Zou, A.P., Billington, H., Su, N., Cowley, A.W. Hypertension (2000)
- Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized rats. Lee, Y.M., Cheng, P.Y., Hong, S.F., Chen, S.Y., Lam, K.K., Sheu, J.R., Yen, M.H. Free Radic. Biol. Med. (2005)
- Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Ushiyama, M., Morita, T., Kuramochi, T., Yagi, S., Katayama, S. Hypertens. Res. (2004)
- Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Pellacani, A., Wiesel, P., Sharma, A., Foster, L.C., Huggins, G.S., Yet, S.F., Perrella, M.A. Circ. Res. (1998)
- Heme oxygenase in diabetes-induced oxidative stress in the heart. Farhangkhoee, H., Khan, Z.A., Mukherjee, S., Cukiernik, M., Barbin, Y.P., Karmazyn, M., Chakrabarti, S. J. Mol. Cell. Cardiol. (2003)
- Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. Trakshel, G.M., Kutty, R.K., Maines, M.D. J. Biol. Chem. (1986)